Skip to main content



IMPORTANT Notice regarding publications and OSUMSC

NIH funded research projects that use the Oregon State University Mass Spectrometry Facility (OSUMSC) and publish mass spectrometry results need to acknowledge the NIH instrument Grant (see below) in the publications using NCBI My Bibliography and/or during uploading of the manuscript to the publisher.

Waters Xevo TQXS Mass Spectrometer - NIH # 1S10OD026922-01

Orbitrap Fusion Lumos -NIH # 1S10OD020111-01

Waters Ion Mobility ToF Mass Spectrometer – NIH #1S10RR025628-01

Applied Biosystems 4000Qtrap- NIH # 1S10RR022589-01

ABSciex Triple ToF 5600-NIH #1S10RR027878-01

Mass Spectrometry Center Publications_2023

1. Bouranis, J. A.; Wong, C.P.; Beaver, L.M.; Uesugi, S.L.; Papenhausen, E.M.; Choi, J.; Davis, E.W.; Da Silva, A.N.; Kalengamaliro, N.; Chaudhary, R.; Kharofa, J.; Takiar, V.; Herzog, T.J.; Barrett, W.; Ho, E. , Sulforaphane Bioavailability in Healthy Subjects Fed a Single Serving of Fresh Broccoli Microgreens. Foods 2023, 12(20). PMC10606698

2. Henderson, T. D.; Choi, J.; Leonard, S. W.; Head, B.; Tanguay, R. L.; Barton, C. L.;Traber, M. G., Chronic Vitamin E Deficiency Dysregulates Purine, Phospholipid, and Amino Acid Metabolism in Aging Zebrafish Skeletal Muscle. Antioxidants (Basel) 2023, 12 (6). PMC10294951

3. Holvoet, H.; Long, D. M.; Yang, L.; Choi, J.; Marney, L.; Poeck, B.; Maier, C. S.; Soumyanath, A.; Kretzschmar, D.;Strauss, R., Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila melanogaster. Nutrients 2023, 15 (18). PMC10537055

4. Jana, S.; Evans, E. G. B.; Jang, H. S.; Zhang, S.; Zhang, H.; Rajca, A.; Gordon, S. E.; Zagotta, W. N.; Stoll, S.;Mehl, R. A., Ultra-Fast Bioorthogonal Spin-Labeling and Distance Measurements in Mammalian Cells Using Small, Genetically Encoded Tetrazine Amino Acids. bioRxiv 2023. PMC9901033

5. Kim, B. J.; Koh, J.; Liang, N. J.; Yang, J.; Ozturk, G.; Barile, D.;Dallas, D. C., Effect of vat pasteurization, ultra-high temperature sterilization, retort sterilization and homogenization on soluble proteins in donor human milk detected via proteomics. Lwt-Food Sci Technol 2023, 182.

6. Koh, J.; Kim, B. J.; Qu, Y.;Dallas, D. C., Mass spectral profiling of caseinomacropeptide extracted from feeding material and jejunal fluid using three methods-ethanol precipitation, perchloric acid precipitation, and ultrafiltration. Food chemistry 2023, 398, 133864. PMID: 35969996

7. Kundu, P.; Yasuhara, K.; Brandes, M. S.; Zweig, J. A.; Neff, C. J.; Holden, S.; Kessler, K.; Matsumoto, S.; Offner, H.; Waslo, C. S.; Vandenbark, A.; Soumyanath, A.; Sherman, L. S.; Raber, J.; Gray, N. E.;Spain, R. I., Centella asiatica promotes antioxidant gene expression and mitochondrial oxidative respiration in experimental autoimmune encephalomyelitis. Res Sq 2023. PMC10602085

8. Newman, N. K.; Zhang, Y.; Padiadpu, J.; Miranda, C. L.; Magana, A. A.; Wong, C. P.; Hioki, K. A.; Pederson, J. W.; Li, Z.; Gurung, M.; Bruce, A. M.; Brown, K.; Bobe, G.; Sharpton, T. J.; Shulzhenko, N.; Maier, C. S.; Stevens, J. F.; Gombart, A. F.;Morgun, A., Reducing gut microbiome-driven adipose tissue inflammation alleviates metabolic syndrome. Microbiome 2023, 11 (1), 208. PMC10512512

9. Qu, Y.; Kim, B. J.; Koh, J.;Dallas, D. C., Comparison of Solid-Phase Extraction Sorbents for Monitoring the In Vivo Intestinal Survival and Digestion of Kappa-Casein-Derived Caseinomacropeptide. Foods 2023, 12 (2). PMC9858392

10. Seufert, A. L.; Hickman, J. W.; Choi, J.;Napier, B. A., Computational Analysis of Plasma Lipidomics from Mice Fed Standard Chow and Ketogenic Diet. Bio Protoc 2023, 13 (18), e4819. PMC10518786

11. Shi, C.; Mahadwar, G.; Davila-Santiago, E.; Bambakidis, T.; Crump, B. C.;Jones, G. D., Nontarget Chemical Composition of Surface Waters May Reflect Ecosystem Processes More than Discrete Source Contributions. Environmental science & technology 2023. PMID: 37235730

12. Spooner, M. H.; Garcia-Jaramillo, M.; Apperson, K. D.; Lohr, C. V.;Jump, D. B., Time course of western diet (WD) induced nonalcoholic steatohepatitis (NASH) in female and male Ldlr-/- mice. PLoS One 2023, 18 (10), e0292432. PMC10566735

13. Thavrin, P.; Choi, J.; Chen, P.; Chen, Q.; Drisko, J.;Stevens, J. F., The Redox Metabolome of Humans Receiving Supraphysiological Doses of Intravenous Vitamin C. Free Radical Bio Med 2023, 201, 20-20.

14. Tomasino, E., Cerrato, D. C., Aragon, M., Fryer, J., Garcia, L., Ashmore, P. L., & Collins, T. S. , A combination of thiophenols and volatile phenols cause the ashy flavor of smoke taint in wine. Food Chemistry Advances 2023.

15. Wright, K. M.; Bollen, M.; David, J.; Mepham, B.; Alcazar Magana, A.; McClure, C.; Maier, C. S.; Quinn, J. F.;Soumyanath, A., Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults. Front Pharmacol 2023, 14, 1228030. PMC10481538

16. Yang, L.; Marney, L.; Magana, A. A.; Choi, J.; Wright, K.; McFerrin, J.; Gray, N. E.; Soumyanath, A.; Stevens, J. F.;Maier, C. S., Quantification of Caffeoylquinic Acids and Triterpenes as Targeted Bioactive Compounds of Centella asiatica in Extracts and Formulations by Liquid Chromatography Mass Spectrometry. J Chromatogr Open 2023, 4. PMC10544816

17. Yang, L.; Stanisheuski, S.; Song, Z.; Bracha, S.;Maier, C. S., Top-down mass spectrometry for characterizing the low molecular weight proteome of canine osteosarcoma cell phenotypes. Eur J Mass Spectrom (Chichester) 2023, 14690667231202766. PMID: 37724027

18. Yap, E. S. P.; Uthairatanakij, A.; Laohakunjit, N.; Jitareerat, P.;Maier, C. S., Targeted and untargeted metabolites and antioxidant properties in chili pepper at different maturity stages. Crop Sci 2023.

19. Zheng, T. J.; Kohs, T. C. L.; Mueller, P. A.; Pang, J.; Reitsma, S. E.; Parra-Izquierdo, I.; Melrose, A. R.; Yang, L.; Choi, J.; Zientek, K. D.; Sviridov, D. O.; Larson, M. K.; Williams, C. D.; Pamir, N.; Shatzel, J. J.; Reddy, A. P.; Kievit, P.; Remaley, A. T.; Stevens, J. F.; Hinds, M. T.; McCarty, O. J. T.;Aslan, J. E., Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity. Blood Adv 2023, 7 (8), 1366-1378. PMC10139943

20. Zhu, P.; Mehl, R. A.;Cooley, R. B., Biosynthesis and Genetic Encoding of Non-hydrolyzable Phosphoserine into Recombinant Proteins in Escherichia coli. Bio Protoc 2023, 13 (21), e4861. PMC10632156

21. Zhu, P.; Nguyen, K. T.; Estelle, A. B.; Sluchanko, N. N.; Mehl, R. A.;Cooley, R. B., Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Protein Sci 2023, 32 (3), e4574. PMID: 36691781

22. Zhu, P.; Stanisheuski, S.; Franklin, R.; Vogel, A.; Vesely, C. H.; Reardon, P.; Sluchanko, N. N.; Beckman, J. S.; Karplus, P. A.; Mehl, R. A.;Cooley, R. B., Autonomous Synthesis of Functional, Permanently Phosphorylated Proteins for Defining the Interactome of Monomeric 14-3-3zeta. ACS Cent Sci 2023, 9 (4), 816-835. PMC10141581

Mass Spectrometry Center Publications_2022

Avila-Crump, S.; Hemshorn, M. L.; Jones, C. M.; Mbengi, L.; Meyer, K.; Griffis, J. A.; Jana, S.; Petrina, G. E.; Pagar, V. V.; Karplus, P. A.; Petersson, E. J.; Perona, J. J.; Mehl, R. A.;Cooley, R. B., Generating Efficient Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids. ACS chemical biology 2022, 17 (12), 3458-3469. PMID: 36383641

Bah, T. M.; Allen, E. M.; Garcia-Jaramillo, M.; Perez, R.; Zarnegarnia, Y.; Davis, C. M.; Bloom, M. B.; Magana, A. A.; Choi, J.; Bobe, G.; Pike, M. M.; Raber, J.; Maier, C. S.;Alkayed, N. J., GPR39 Deficiency Impairs Memory and Alters Oxylipins and Inflammatory Cytokines Without Affecting Cerebral Blood Flow in a High-Fat Diet Mouse Model of Cognitive Impairment. Front Cell Neurosci 2022, 16, 893030. PMID: 35875352

Bouranis, J. A.; Beaver, L. M.; Jiang, D.; Choi, J.; Wong, C. P.; Davis, E. W.; Williams, D. E.; Sharpton, T. J.; Stevens, J. F.;Ho, E., Interplay between Cruciferous Vegetables and the Gut Microbiome: A Multi-Omic Approach. Nutrients 2022, 15 (1). PMID: 36615700

Brown, K. S.; Jamieson, P.; Wu, W.; Vaswani, A.; Alcazar Magana, A.; Choi, J.; Mattio, L. M.; Cheong, P. H.; Nelson, D.; Reardon, P. N.; Miranda, C. L.; Maier, C. S.;Stevens, J. F., Computation-Assisted Identification of Bioactive Compounds in Botanical Extracts: A Case Study of Anti-Inflammatory Natural Products from Hops. Antioxidants (Basel) 2022, 11 (7). PMID: 35883889

Cabey, K.; Long, D. M.; Law, A.; Gray, N. E.; McClure, C.; Caruso, M.; Lak, P.; Wright, K. M.; Stevens, J. F.; Maier, C. S.; Soumyanath, A.;Kretzschmar, D., Withania somnifera and Centella asiatica Extracts Ameliorate Behavioral Deficits in an In Vivo Drosophila melanogaster Model of Oxidative Stress. Antioxidants (Basel) 2022, 11 (1). PMCID: PMC8773428

Chen, Y.; Kim, B. J.;Dallas, D. C., Proteomics analysis reveals digestion-resistant proteins from colostrum are associated with inflammatory and cytotoxic responses in intestinal epithelial cells. JPEN. Journal of parenteral and enteral nutrition 2022, 46 (5), 1119-1129. PMID: 34687453

Davila-Santiago, E.; Shi, C.; Mahadwar, G.; Medeghini, B.; Insinga, L.; Hutchinson, R.; Good, S.;Jones, G. D., Machine Learning Applications for Chemical Fingerprinting and Environmental Source Tracking Using Non-target Chemical Data. Environmental science & technology 2022, 56 (7), 4080-4090. PMID: 35297611

Ferraris, Q.; Alcazar, A.;Qian, M. C., Profiling polar lipids in whey protein phospholipid concentrate by LC-HRMS/MS. Food chemistry 2022, 374, 131495. PMID: 34776307

Holvoet, H.; Long, D. M.; Law, A.; McClure, C.; Choi, J.; Yang, L.; Marney, L.; Poeck, B.; Strauss, R.; Stevens, J. F.; Maier, C. S.; Soumyanath, A.;Kretzschmar, D., Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides. Nutrients 2022, 14 (19). PMID: 36235577

Huang, L.; Alcazar Magana, A.; Skinkis, P. A.; Osborne, J.; Qian, Y. L.;Qian, M. C., Composition of Pinot Noir Wine from Grapevine Red Blotch Disease-Infected Vines Managed with Exogenous Abscisic Acid Applications. Molecules 2022, 27 (14). PMID: 35889392

Keller, R. M.; Beaver, L. M.; Prater, M. C.; Truong, L.; Tanguay, R. L.; Stevens, J. F.;Hord, N. G., Nitrate exposure reprograms hepatic amino acid and nutrient sensing pathways prior to exercise: A metabolomic and transcriptomic investigation in zebrafish (Danio rerio). Frontiers in molecular biosciences 2022, 9, 903130. PMID: 35928228

Khorani, M.; Bobe, G.; Matthews, D. G.; Magana, A. A.; Caruso, M.; Gray, N. E.; Quinn, J. F.; Stevens, J. F.; Soumyanath, A.;Maier, C. S., The Impact of the hAPP695SW Transgene and Associated Amyloid-beta Accumulation on Murine Hippocampal Biochemical Pathways. J Alzheimers Dis 2022, 85 (4), 1601-1619. PMID: 34958022

Koh, J.; Kim, B. J.; Qu, Y.; Huang, H.;Dallas, D. C., Top-Down Glycopeptidomics Reveals Intact Glycomacropeptide Is Digested to a Wide Array of Peptides in Human Jejunum. J Nutr 2022, 152 (2), 429-438. PMID: 34850069

Kundu, P.; Holden, S.; Paraiso, I. L.; Sudhakar, R.; McQuesten, C.; Choi, J.; Miranda, C. L.; Maier, C. S.; Bobe, G.; Stevens, J. F.;Raber, J., ApoE isoform-dependent effects of xanthohumol on high fat diet-induced cognitive impairments and hippocampal metabolic pathways. Front Pharmacol 2022, 13, 954980. PMID: 36278228

Kundu, P.; Paraiso, I. L.; Choi, J.; Miranda, C. L.; Kioussi, C.; Maier, C. S.; Bobe, G.; Stevens, J. F.;Raber, J., Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet. Dis Model Mech 2022, 15 (11). PMID: 36353888

Langley, B. O.; Ryan, J. J.; Phipps, J.; Buttolph, L.; Bray, B.; Aslan, J. E.; Metz, T. O.; Stevens, J. F.;Bradley, R., Xanthohumol microbiome and signature in adults with Crohn's disease (the XMaS trial): a protocol for a phase II triple-masked, placebo-controlled clinical trial. Trials 2022, 23 (1), 885. PMID: 36273173

Liang, N.; Beverly, R. L.; Scottoline, B. P.;Dallas, D. C., Peptides Derived from In Vitro and In Vivo Digestion of Human Milk Are Immunomodulatory in THP-1 Human Macrophages. J Nutr 2022, 152 (1), 331-342. PMID: 34601601

Liang, N.; Kim, B. J.;Dallas, D. C., Bioavailability of Peptides Derived from the In Vitro Digestion of Human Milk Assessed by Caco-2 Cell Monolayers. J Agric Food Chem 2022, 70 (23), 7077-7084. PMID: 35608350

Miranda, C. L.; Kumbi, Y.; Wu, W.; Lee, H. S.; Reed, R. L.;Stevens, J. F., Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts of Fagonia indica. Nat Prod Commun 2022, 17 (7). PMID: 35875707

Reitsma, S. E.; Lakshmanan, H. H. S.; Johnson, J.; Pang, J.; Parra-Izquierdo, I.; Melrose, A. R.; Choi, J.; Anderson, D. E. J.; Hinds, M. T.; Stevens, J. F.; Aslan, J. E.; McCarty, O. J. T.;Lo, J. O., Chronic edible dosing of Delta9-tetrahydrocannabinol (THC) in nonhuman primates reduces systemic platelet activity and function. American journal of physiology Cell physiology 2022, 322 (3), C370-C381. PMID: 35080922

Revel, J. S.; Alcazar Magana, A.; Morre, J.; Deluc, L.;Maier, C. S., Gas Chromatography Coupled to Atmospheric Pressure Chemical Ionization High-Resolution Mass Spectrometry for Metabolite Fingerprinting of Grape (Vitis vinifera L) Berry. Methods Mol Biol 2022, 2396, 85-99. PMID: 34786678

Shankar, P.; Garcia, G. R.; La Du, J. K.; Sullivan, C. M.; Dunham, C. L.; Goodale, B. C.; Waters, K. M.; Stanisheuski, S.; Maier, C. S.; Thunga, P.; Reif, D. M.;Tanguay, R. L., The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicological sciences : an official journal of the Society of Toxicology 2022, 187 (2), 325-344. PMCID: PMC9308396

Van Fossen, E. M.; Grutzius, S.; Ruby, C. E.; Mourich, D. V.; Cebra, C.; Bracha, S.; Karplus, P. A.; Cooley, R. B.;Mehl, R. A., Creating a Selective Nanobody Against 3-Nitrotyrosine Containing Proteins. Frontiers in chemistry 2022, 10, 835229. PMCID: PMC8899190

Wright, K. M.; Bollen, M.; David, J.; Speers, A. B.; Brandes, M. S.; Gray, N. E.; Alcazar Magana, A.; McClure, C.; Stevens, J. F.; Maier, C. S.; Quinn, J. F.;Soumyanath, A., Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial. Antioxidants (Basel) 2022, 11 (2). PMCID: PMC8868383

Mass Spectrometry Center Publications_2021

Beverly, R. L.; Huston, R. K.; Markell, A. M.; McCulley, E. A.; Martin, R. L.;Dallas, D. C., Differences in human milk peptide release along the gastrointestinal tract between preterm and term infants. Clin Nutr 2021, 40 (3), 1214-1223. PMCID: PMC7865014

Beverly, R. L.; Woonnimani, P.; Scottoline, B. P.; Lueangsakulthai, J.;Dallas, D. C., Peptides from the Intestinal Tract of Breast Milk-Fed Infants Have Antimicrobial and Bifidogenic Activity. International journal of molecular sciences 2021, 22 (5). PMCID: PMC7956819

Bouranis, J. A.; Beaver, L. M.; Choi, J.; Wong, C. P.; Jiang, D.; Sharpton, T. J.; Stevens, J. F.; Ho, E., Composition of the gut microbiome influences production of sulforaphane-nitrile and iberin-nitrile from glucosinolate in Broccoli Sprouts. Nutrients 2021, 13 (9), 3013

Chan, L. E.; Beverly, R. L.; Dallas, D. C., The enzymology of human milk. Agents of changes 2021, 209-243.

Keller, R. M.; Beaver, L. M.; Reardon, P. N.; Prater, M. C.; Truong, L.; Robinson, M. M.; Tanguay, R. L.; Stevens, J. F.;Hord, N. G., Nitrate-induced improvements in exercise performance are coincident with exuberant changes in metabolic genes and the metabolome in zebrafish (Danio rerio) skeletal muscle. J Appl Physiol (1985) 2021, 131 (1), 142-157. PMCID: PMC34043471 (Available on 2022-07-01)

Kim, B. J.;Dallas, D. C., Systematic examination of protein extraction, proteolytic glycopeptide enrichment and MS/MS fragmentation techniques for site-specific profiling of human milk N-glycoproteins. Talanta 2021, 224, 121811. PMCID: PMC7775605 (Available on 2022-03-01)

Le, D. E.; Garcia-Jaramillo, M.; Bobe, G.; Alcazar Magana, A.; Vaswani, A.; Minnier, J.; Jump, D. B.; Rinkevich, D.; Alkayed, N. J.; Maier, C. S.; Kaul, S., Plasma Oxylipins: A Potential Risk Assessment Tool in Atherosclerotic Coronary Artery Disease. Frontiers in cardiovascular medicine 2021, 8, 645786. PMCID: PMC8097092

Logan, I. E.; Shulzhenko, N.; Sharpton, T. J.; Bobe, G.; Liu, K.; Nuss, S.; Jones, M. L.; Miranda, C. L.; Vasquez-Perez, S.; Pennington, J. M.; Leonard, S. W.; Choi, J.; Wu, W.; Gurung, M.; Kim, J. P.; Lowry, M. B.; Morgun, A.; Maier, S. C.; Stevens, J. F.; Gombart, A. F., Xanthohumol requires the intestinal microbiota to improve glucose metabolism in Diet-induced obese mice. Mol Nutr Food Res. 2021 PMID: 34496124

Magana, A. A.; Kamimura, N.; Soumyanath, A.; Stevens, J. F.; Maier, C. S., Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity. Plant J. 2021 PMID: 34171156

Maier, M. L. V.; Siddens, L. K.; Uesugi, S. L.; Choi, J.; Leonard, S. W.; Pennington, J. M.; Tilton, S. C.; Smith, J. N.; Ho, E.; Chow, H. H. S.; Nguyen, B. D.; Kolluri, S. K.; Williams, D. E., 3,3’-Diindolylmethane exhibits significant metabolism after oral dosing in humans. Drug Metab Dispos. 2021, 49 (8), 694-705. PMID: 34035125

Milone, J. P.; Chakrabarti, P.; Sagili, R. R.;Tarpy, D. R., Colony-level pesticide exposure affects honey bee (Apis mellifera L.) royal jelly production and nutritional composition. Chemosphere 2021, 263, 128183. PMID: 33297150

Noell, S. E.; Barrell, G. E.; Suffridge, C.; Morre, J.; Gable, K. P.; Graff, J. R.; VerWey, B. J.; Hellweger, F. L.;Giovannoni, S. J., SAR11 Cells Rely on Enzyme Multifunctionality To Metabolize a Range of Polyamine Compounds. mBio 2021, e0109121. PMID: 34425701

Paraiso, I. L.; Tran, T. Q.; Magana, A. A.; Kundu, P.; Choi, J.; Maier, C. S.; Bobe, G.; Raber, J.; Kioussi, C.;Stevens, J. F., Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling. Front Pharmacol 2021, 12, 643857. PMCID: PMC8093804

Phan, Q.;Tomasino, E., Untargeted lipidomic approach in studying pinot noir wine lipids and predicting wine origin. Food chemistry 2021, 355, 129409. PMID: 33799257

Phillips, I. L.; Danelishvili, L.;Bermudez, L. E., Macrophage Proteome Analysis at Different Stages of Mycobacterium avium Subspecies paratuberculosis Infection Reveals a Mechanism of Pathogen Dissemination. Proteomes 2021, 9 (2). PMCID: PMC8162536

Raber, J.; Perez, R.; Torres, E. R. S.; Krenik, D.; Boutros, S.; Patel, E.; Chlebowski, A. C.; Torres, E. R.; Perveen, Z.; Penn, A.; Paulsen, D. B.; Bartlett, M. G.; Jia, E.; Holden, S.; Hall, R.; Morre, J.; Wong, C.; Ho, E.; Choi, J.; Stevens, J. F.; Noel, A.; Bobe, G.;Kisby, G., Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice. Environmental health perspectives 2021, 129 (5), 57009. PMCID: PMC8132614

Vaswani, A.; Alcazar Magana, A.; Zimmermann, E.; Hasan, W.; Raman, J.; Maier, C. S., Comparative liquid chromatography/tandem mass spectrometry lipidomics analysis of macaque heart tissue flash-frozen or embedded in optimal cutting temperature polymer (OCT): Practical considerations. Rapid Commun Mass Spectrom 2021, 35 (18), e9155. PMID: 34169582

Weinman, M. A.; Ramsey, S. A.; Leeper, H. J.; Brady, J. V.; Schlueter, A.; Stanisheuski, S.; Maier, C. S.; Miller, T.; Ruby, C. E.;Bracha, S., Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma. Cancer cell international 2021, 21 (1), 245. PMCID: PMC8088716

Yap, E. S. P.; Uthairatanakij, A.; Laohakunjit, N.; Jitareerat, P.; Vaswani, A.; Magana, A. A.; Morre, J.;Maier, C. S., Plant growth and metabolic changes in 'Super Hot' chili fruit (Capsicum annuum) exposed to supplemental LED lights. Plant science : an international journal of experimental plant biology 2021, 305, 110826. PMID: 33691960

Zhang, Y.; Bobe, G.; Miranda, C. L.; Lowry, M. B.; Hsu, V. L.; Lohr, C. V.; Wong, C. P.; Jump, D. B.; Robinson, M. M.; Sharpton, T. J.; Maier, C. S.; Stevens, J. F.;Gombart, A. F., Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARgamma. eLife 2021, 10. PMCID: PMC8205491

Mass Spectrometry Center Publications_2020

Alcazar Magana, A.; Wright, K.; Vaswani, A.; Caruso, M.; Reed, R. L.; Bailey, C. F.; Nguyen, T.; Gray, N. E.; Soumyanath, A.; Quinn, J.; Stevens, J. F.;Maier, C. S., Integration of mass spectral fingerprinting analysis with precursor ion (MS1) quantification for the characterisation of botanical extracts: application to extracts of Centella asiatica (L.) Urban. Phytochemical analysis : PCA 2020. PMID: 32281154

Alcazar Magana, A. A.; Reed, R. L.; Koluda, R.; Miranda, C. L.; Maier, C. S.;Stevens, J. F., Vitamin C Activates the Folate-Mediated One-Carbon Cycle in C2C12 Myoblasts. Antioxidants (Basel) 2020,9 (3). PMCID: PMC7139526

Beyer, J. N.; Hosseinzadeh, P.; Gottfried-Lee, I.; Van Fossen, E. M.; Zhu, P.; Bednar, R. M.; Karplus, P. A.; Mehl, R. A.;Cooley, R. B., Overcoming Near-Cognate Suppression in a Release Factor 1-Deficient Host with an Improved Nitro-Tyrosine tRNA Synthetase. J Mol Biol 2020, 432 (16), 4690-4704. PMID: 32569745

Beverly, R. L.; Huston, R. K.; Markell, A. M.; McCulley, E. A.; Martin, R. L.;Dallas, D. C., Differences in human milk peptide release along the gastrointestinal tract between preterm and term infants. Clin Nutr 2020. PMID: 32800606

Beverly, R. L.; Huston, R. K.; Markell, A. M.; McCulley, E. A.; Martin, R. L.;Dallas, D. C., Milk peptides survive in vivo gastrointestinal digestion and are excreted in the stool of infants. J Nutr. 2020. 150(4) PMCID: PMC7138664

Chakrabarti, P.; Sagili, R. R., Changes in Honey Bee Head Proteome in Response to Dietary 24-Methylenecholesterol. Insects 2020, 11 (11) PMCID: PMC7693931

Fraser, V. N.; Philmus, B.;Megraw, M., Metabolomics analysis reveals both plant variety and choice of hormone treatment modulate vinca alkaloid production in Catharanthus roseus. Plant direct 2020, 4 (9), e00267. PMCID: PMC7520646

Garcia-Jaramillo, M.; Beaver, L. M.; Truong, L.; Axton, E. R.; Keller, R. M.; Prater, M. C.; Magnusson, K. R.; Tanguay, R. L.; Stevens, J. F.;Hord, N. G., Nitrate and nitrite exposure leads to mild anxiogenic-like behavior and alters brain metabolomic profile in zebrafish. PLoS One 2020, 15 (12), e0240070. PMCID: PMC7774831

Jang, H. S.; Gu, X. D.; Cooley, R. B.; Porter, J. J.; Henson, R. L.; Willi, T.; DiDonato, J. A.; Hazen, S. L.;Mehl, R. A., (2020). "Efficient Site-Specific Prokaryotic and Eukaryotic Incorporation of Halotyrosine Amino Acids into Proteins." ACS Chem Biol 15(2): 562-574. PMID: 31994864

Kim, B. J.;Dallas, D. C., Systematic examination of protein extraction, proteolytic glycopeptide enrichment and MS/MS fragmentation techniques for site-specific profiling of human milk N-glycoproteins. Talanta 2021, 224, 121811 PMID: 33379036

Kim, B. J.; Lueangsakulthai, J.; Sah, B. N. P.; Scottoline, B.;Dallas, D. C., Quantitative Analysis of Antibody Survival across the Infant Digestive Tract Using Mass Spectrometry with Parallel Reaction Monitoring. Foods 2020, 9 (6). PMCID: PMC7353590

Logan, I. E.; Bobe, G.; Miranda, C. L.; Vasquez-Perez, S.; Choi, J.; Lowry, M. B.; Sharpton, T. J.; Morgun, A.; Maier, C. S.; Stevens, J. F.; Shulzhenko, N.;Gombart, A. F., Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia. Microorganisms 2020, 8 (4). PMCID: PMC7232377

Lueangsakulthai, J.; Kim, B. J.; Demers-Mathieu, V.; Sah, B. N. P.; Woo, Y.; Olyaei, A.; Aloia, M.; O'Connor, A.; Scottoline, B. P.;Dallas, D. C., Effect of digestion on stability of palivizumab IgG1 in the infant gastrointestinal tract. Pediatric research 2020. PMID: 33214672

Matthews, D. G.; Caruso, M.; Alcazar Magana, A.; Wright, K. M.; Maier, C. S.; Stevens, J. F.; Gray, N. E.; Quinn, J. F.;Soumyanath, A., Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer's Disease Model Mice. Nutrients 2020, 12 (11) PMCID: PMC7698091

Nielsen, S. D.; Beverly, R. L.; Underwood, M. A.;Dallas, D. C., Differences and Similarities in the Peptide Profile of Preterm and Term Mother's Milk, and Preterm and Term Infant Gastric Samples. Nutrients 2020, 12 (9). PMCID: PMC7551100

Parachini-Winter, C.; Bracha, S.; Ramsey, S. A.; Yang, L.; Ho, E.; Leeper, H. J.;Curran, K. M., Prospective evaluation of the lymph node proteome in dogs with multicentric lymphoma supplemented with sulforaphane. Journal of veterinary internal medicine 2020, 34 (5), 2036-2047. PMCID: PMC7517837

Paraiso, I. L.; Revel, J. S.; Choi, J.; Miranda, C. L.; Lak, P.; Kioussi, C.; Bobe, G.; Gombart, A. F.; Raber, J.; Maier, C. S.;Stevens, J. F., Targeting the Liver-Brain Axis with Hop-Derived Flavonoids Improves Lipid Metabolism and Cognitive Performance in Mice. Mol Nutr Food Res 2020, 64 (15), e2000341 PMID: 32627931

Preston, G. W.; Yang, L.; Phillips, D. H.;Maier, C. S., Visualisation tools for dependent peptide searches to support the exploration of in vitro protein modifications. PLoS One 2020, 15 (7), e0235263. PMCID: PMC7343161

Porter, J. J.; Jang, H. S.; Haque, M. M.; Stuehr, D. J.;Mehl, R. A., (2020). "Tyrosine nitration on calmodulin enhances calcium-dependent association and activation of nitric-oxide synthase." Journal of Biological Chemistry 295(8): 2203-2211. PMCID: PMC7039552

Redanz, S.; Treerat, P.; Mu, R.; Redanz, U.; Zou, Z.; Koley, D.; Merritt, J.;Kreth, J., Pyruvate secretion by oral streptococci modulates hydrogen peroxide dependent antagonism. The ISME journal 2020, 14 (5), 1074-1088. PMID: 31988475

Sah, B. N. P.; Lueangsakulthai, J.; Kim, B. J.; Hauser, B. R.; Woo, Y.; Olyaei, A.; Aloia, M.; O'Connor, A.; Scottoline, B.; Pastey, M. K.;Dallas, D. C., Partial Degradation of Recombinant Antibody Functional Activity During Infant Gastrointestinal Digestion: Implications for Oral Antibody Supplementation. Frontiers in nutrition 2020, 7, 130. PMCID: PMC7456970

Selamassakul, O.; Laohakunjit, N.; Kerdchoechuen, O.; Yang, L.;Maier, C. S., (2020). "Bioactive peptides from brown rice protein hydrolyzed by bromelain: Relationship between biofunctional activities and flavor characteristics." J Food Sci 85(3): 707-717. PMID: 32043604

Shoaib, M.; Choudhary, R. C.; Choi, J.; Kim, N.; Hayashida, K.; Yagi, T.; Yin, T.; Nishikimi, M.; Stevens, J. F.; Becker, L. B.;Kim, J., Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations. Scientific reports 2020, 10 (1), 19707. PMCID: PMC7665036

Song, Z.; Pearce, M. C.; Jiang, Y.; Yang, L.; Goodall, C.; Miranda, C. L.; Milovancev, M.; Bracha, S.; Kolluri, S. K.;Maier, C. S., (2020). "Delineation of hypoxia-induced proteome shifts in osteosarcoma cells with different metastatic propensities." Sci Rep 10(1): 727. PMCID: PMC6971036

Suffridge, C. P.; Bolanos, L. M.; Bergauer, K.; Worden, A. Z.; Morr, J.; Behrenfeld, M. J.;Giovannoni, S. J., Exploring Vitamin B1 Cycling and Its Connections to the Microbial Community in the North Atlantic Ocean. Front Mar Sci 2020, 7.

Wright, K. M.; Alcazar Magana, A.; Laethem, R. M.; Moseley, C. L.; Banks, T. T.; Maier, C. S.; Stevens, J. F.; Quinn, J. F.;Soumyanath, A., Centella asiatica water extract shows low potential for CYP-mediated drug interactions. Drug metabolism and disposition: the biological fate of chemicals 2020. PMID: 32581050

Zhang, Y.; Bobe, G.; Revel, J. S.; Rodrigues, R. R.; Sharpton, T. J.; Fantacone, M. L.; Raslan, K.; Miranda, C. L.; Lowry, M. B.; Blakemore, P. R.; Morgun, A.; Shulzhenko, N.; Maier, C. S.; Stevens, J. F.;Gombart, A. F., (2020). "Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism." Mol Nutr Food Res 64(1): e1900789. PMCID: PMC6918268

Mass Spectrometry Center Publications_2019

Allan, E. R. O., Yang, L., Tennessen, J. A., & Blouin, M. S. (2019). Allelic variation in a single genomic region alters the hemolymph proteome in the snail Biomphalaria glabrata. Fish Shellfish Immunol, 88, 301-307. PMCID: PMC6687060

Axton, E. R., Beaver, L. M., St Mary, L., Truong, L., Logan, C. R., Spagnoli, S., Prater, M. C., Keller, R. M., Garcia-Jaramillo, M., Ehrlicher, S. E., Stierwalt, H. D., Newsom, S. A., Robinson, M. M., Tanguay, R. L., Stevens, J. F., & Hord, N. G. (2019). Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish. J Nutr. PMID: 31495890

Bednar, R. M., Golbek, T. W., Kean, K. M., Brown, W. J., Jana, S., Baio, J. E., Karplus, P. A., & Mehl, R. A. (2019). Immobilization of Proteins with Controlled Load and Orientation. ACS Appl Mater Interfaces, 11(40), 36391-36398 PMID: 31525993

Beverly, L., Underwood, M., Dallas, D. (2019) Peptidomics analysis of milk protein-derived peptides released over time in the pretem infant stomach. J Proteome Res. 18(3): 911-922 PMCID: PMC6472904

Chakrabarti, P., Morre, J., Lucas, H., Maier, C., Sagili R. (2019) The omics approach to bee nutritional landscape. Metabolomics, 15(10): 127 PMID: 31538263

Chen, Y., Danelishvili, L., Rose, S. J., & Bermudez, L. E. (2019). Mycobacterium bovis BCG Surface Antigens Expressed under the Granuloma-Like Conditions as Potential Inducers of the Protective Immunity. Int J Microbiol, 2019, 9167271. PMCID: PMC6589241

Chiplunkar, S. S., Silva, C. A., Bermudez, L. E., & Danelishvili, L. (2019). Characterization of membrane vesicles released by Mycobacterium avium in response to environment mimicking the macrophage phagosome. Future Microbiol. PMCID:PMC6479280

Choi, J., Shoaib, M., Yin, T., Nayyar, G., Shinozaki, K., Stevens, J. F., Becker, L. B., & Kim, J. (2019). Tissue-Specific Metabolic Profiles After Prolonged Cardiac Arrest Reveal Brain Metabolome Dysfunction Predominantly After Resuscitation. J Am Heart Assoc, 8(17), e012809. PMCID:PMC6755859

Deng, C. L., Bard, J. P., Zakharov, L. N., Johnson, D. W., & Haley, M. M. (2019a). Naphtho[2,1- e]-1,2-azaphosphorine 2-Oxide Derivatives: Synthesis, Optoelectronic Properties, and Self-Dimerization Phenomena. J Org Chem, 84(12), 8131-8139. PMID: 31117581

Deng, C. L., Bard, J. P., Zakharov, L. N., Johnson, D. W., & Haley, M. M. (2019b). PN-Containing Pyrene Derivatives: Synthesis, Structure, and Photophysical Properties. Org Lett, 21(16), 6427-6431. PMID: 31348670

Eida, A. A., Abugrain, M. E., Brumsted, C. J., & Mahmud, T. (2019). Glycosylation of acyl carrier protein-bound polyketides during pactamycin biosynthesis. Nat Chem Biol, 15(8), 795-802. PMCID: PMC6642016

El-Mansy, M., Ghosh, A., Cheong, P. H. Y., & Carter, R. (2019). Regioselective lithiation of benzyl imidazole: Synthesis and evaluation of new organocatalysts for trans-diol functionalization. Synthetic Communications, 49(22), 3131-3139.

Garcia-Jaramillo, M., K. A. Lytle, et al. (2019). "A Lipidomic Analysis of Docosahexaenoic Acid (22:6, omega3) Mediated Attenuation of Western Diet Induced Nonalcoholic Steatohepatitis in Male Ldlr (-/-) Mice." Metabolites 9(11). PMCID: PMC6918288

Garcia-Jaramillo, M., Spooner, M. H., Lohr, C. V., Wong, C. P., Zhang, W., & Jump, D. B. (2019). Lipidomic and transcriptomic analysis of western diet-induced nonalcoholic steatohepatitis (NASH) in female Ldlr -/- mice. PLoS One, 14(4), e0214387. PMCID: PMC6447358

Ghosh, A., Brueckner, A. C., Cheong, P. H., & Carter, R. G. (2019). Second-Generation Synthesis of the Northern Fragment of Mandelalide A: Role of pi-Stacking on Sharpless Dihydroxylation of cis-Enynes. J Org Chem, 84(14), 9196-9214. PMID: 31264876

Lande, C., Rao, S., Morre, J. T., Galindo, G., Kirby, J., Reardon, P. N., Bobe, G., & Stevens, J. F. (2019). Linden (Tilia cordata) associated bumble bee mortality: Metabolomic analysis of nectar and bee muscle. PLoS One, 14(7), e0218406 PMCID: PMC6619659

Lazar, I. M., Deng, J., Stremler, M. A., & Ahuja, S. (2019). Microfluidic reactors for advancing the MS analysis of fast biological responses. Microsyst Nanoeng, 5, 7. PMCID: PMC6369226

Lewis, M. S., Danelishvili, L., Rose, S. J., & Bermudez, L. E. (2019). MAV_4644 Interaction with the Host Cathepsin Z Protects Mycobacterium avium subsp. hominissuis from Rapid Macrophage Killing. Microorganisms, 7(5). PMCID: PMC6560410

Manuel Garcia-Jaramillo, K. A. L., Melinda H. Spooner, Donald B. Jump. (2019). A Lipidomic Analysis of Docosahexaenoic Acid (22:6, ω3) Mediated Attenuation of Western Diet Induced Nonalcoholic Steatohepatitis in Male Ldlr -/- Mice. Metabolites, 9(11). PMID: 31661783

Paraiso, I., Plagmann, L., Yang, L., Zielke, R., Gombart, A., Maier, C., Sikora, A., Blakemore, P., Stevens, J. (2019). Reductive metabolism of xanthohumol and 8-prenylnaringenin by the intestinal bacterium eubacterium ramulus. Mol Nutr Food Res. 63(2): e1800923 PMCID: PMC6561348

Pedroarena, J.R., Nell, B.P., Zakharov, L.N., Tyler, D.R., (2019). Synthesis of Unsymmetrical Bis(phosphine) Oxides and Their Phosphines via Secondary Phosphine Oxide Precursors. Journal of Inorganic and Organometallic Polymers and Materials, 1-10.

Porter, J. J., Jang, H. S., Van Fossen, E. M., Nguyen, D. P., Willi, T. S., Cooley, R. B., & Mehl, R. A. (2019). Genetically Encoded Protein Tyrosine Nitration in Mammalian Cells. ACS Chem Biol, 14(6), 1328-1336. PMID: 31117397

Sall, K., Dekkers, B. J. W., Nonogaki, M., Katsuragawa, Y., Koyari, R., Hendrix, D., Willems, L. A. J., Bentsink, L., & Nonogaki, H. (2019). DELAY OF GERMINATION 1-LIKE 4 acts as an inducer of seed reserve accumulation. Plant Journal, 100(1), 7-19. PMID: 31359518

Torres, E. R. S., Hall, R., Bobe, G., Choi, J., Impey, S., Pelz, C., Lindner, J. R., Stevens, J. F., & Raber, J. (2019). Integrated Metabolomics-DNA Methylation Analysis Reveals Significant Long-Term Tissue-Dependent Directional Alterations in Aminoacyl-tRNA Biosynthesis in the Left Ventricle of the Heart and Hippocampus Following Proton Irradiation. Front Mol Biosci, 6, 77. PMCID: PMC6746933

Zhang, Y., Bobe, G., Revel, J. S., Rodrigues, R., Sharpton, T. J., Fantacone, M. L., Raslan, K., Miranda, C. L., Lowry, M. B., Blakemore, P. R., Morgun, A., Shulzhenko, N., Maier, C. S., Stevens, J. F., & Gombart, A. F. (2019). Improvements in Metabolic Syndrome by Xanthohumol Derivatives are Linked to Altered Gut Microbiota and Bile Acid Metabolism. Mol Nutr Food Res, e1900789. PMID: 31755244

Zhang, Z. Z., Garzotto, M., Davis, E. W., Mori, M., Stoller, W. A., Farris, P. E., Wong, C. P., Beaver, L. M., Thomas, G. V., Williams, D. E., Dashwood, R. H., Hendrix, D. A., Ho, E., & Shannon, J. (2019). Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial. Nutrition and Cancer-an International Journal. PMID: 31155953

Mass Spectrometry Center Publications_2018

Ahn, S., Magana, A. A., Bozarth, C., Shepardson, J., Morre, J., Dreher, T., & Maier, C. S. (2018). Integrated identification and quantification of cyanobacterial toxins from Pacific Northwest freshwaters by Liquid Chromatography and High-resolution Mass Spectrometry. J Mex Chem Soc, 62(2). PMCID: PMC6133267

Axton, E. R., Cristobal, E., Choi, J., Miranda, C. L., & Stevens, J. F. (2018). Metabolomics-Driven Elucidation of Cellular Nitrate Tolerance Reveals Ascorbic Acid Prevents Nitroglycerin-Induced Inactivation of Xanthine Oxidase. Frontiers in Pharmacology, 9, 1085. PMCID: PMC6167911

Babrak, L., & Bermudez, L. E. (2018). Response of the respiratory mucosal cells to mycobacterium avium subsp. Hominissuis microaggregate. Arch Microbiol, 200(5), 729-742. PMID: 29383404

Bayissi Bading-Taikaa, T. A., Armando Alcazar Maganad, Jaewoo Choi,, Michael Ouanesisouk, E. R. S. T., Lisa A. Lione, Claudia S. Maier,, & Gerd Bobe, J. R., Cristobal L. Miranda and Jan F. Stevens. (2018). Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice. Journal of Food Bioactives, 3. PMCID: PMC6301038

Brady, J. V., Troyer, R. M., Ramsey, S. A., Leeper, H., Yang, L., Maier, C. S., Goodall, C. P., Ruby, C. E., Albarqi, H. A. M., Taratula, O., & Bracha, S. (2018). A Preliminary Proteomic Investigation of Circulating Exosomes and Discovery of Biomarkers Associated with the Progression of Osteosarcoma in a Clinical Model of Spontaneous Disease. Transl Oncol, 11(5), 1137-1146. PMCID: PMC6077151

Choi, J., Yin, T., Shinozaki, K., Lampe, J. W., Stevens, J. F., Becker, L. B., & Kim, J. (2018). Comprehensive analysis of phospholipids in the brain, heart, kidney, and liver: brain phospholipids are least enriched with polyunsaturated fatty acids. Mol Cell Biochem, 442(1-2), 187-201. PMCID: PMC5882520

Curran, K. M., Bracha, S., Wong, C. P., Beaver, L. M., Stevens, J. F., & Ho, E. (2018). Sulforaphane absorption and histone deacetylase activity following single dosing of broccoli sprout supplement in normal dogs. Vet Med Sci. PMCID: PMC6236138

Danelishvili, L., Rojony, R., Carson, K. L., Palmer, A. L., Rose, S. J., & Bermudez, L. E. (2018). Mycobacterium avium subsp. hominissuis effector MAVA5_06970 promotes rapid apoptosis in secondary-infected macrophages during cell-to-cell spread. Virulence, 9(1), 1287-1300. PMCID: PMC6177253

Demers-Mathieu, V., Underwood, M. A., Beverly, R. L., & Dallas, D. C. (2018). Survival of Immunoglobulins from Human Milk to Preterm Infant Gastric Samples at 1, 2, and 3 h Postprandial. Neonatology, 114(3), 242-250. PMCID: PMC6217945

Demers-Mathieu, V., Underwood, M. A., Beverly, R. L., Nielsen, S. D., & Dallas, D. C. (2018). Comparison of Human Milk Immunoglobulin Survival during Gastric Digestion between Preterm and Term Infants. Nutrients, 10(5). PMCID: PMC5986510

Dressler, J. J., Teraoka, M., Espejo, G. L., Kishi, R., Takamuku, S., Gomez-Garcia, C. J., Zakharov, L. N., Nakano, M., Casado, J., & Haley, M. M. (2018). Thiophene and its sulfur inhibit indenoindenodibenzothiophene diradicals from low-energy lying thermal triplets. Nat Chem, 10(11), 1134-1140. PMID: 30224686

Everman, J. L., Danelishvili, L., Flores, L. G., & Bermudez, L. E. (2018). MAP1203 Promotes Mycobacterium avium Subspecies paratuberculosis Binding and Invasion to Bovine Epithelial Cells. Front Cell Infect Microbiol, 8, 217. PMCID: PMC6030366

Eytel, L. M., Brueckner, A. C., Lohrman, J. A., Haley, M. M., Cheong, P. H., & Johnson, D. W. (2018). Conformationally flexible arylethynyl bis-urea receptors bind disparate oxoanions with similar, high affinities. Chem Commun (Camb), 54(94), 13208-13211. PMID: 30298881

Goswami, S., Harada, K., El-Mansy, M. F., Lingampally, R., & Carter, R. G. (2018). Enantioselective Synthesis of (-)-Halenaquinone. Angew Chem Int Ed Engl, 57(29), 9117-9121. PMID: 29920904

Gray, N. E., Magana, A. A., Lak, P., Wright, K. M., Quinn, J., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2018). Centella asiatica: phytochemistry and mechanisms of neuroprotection and cognitive enhancement. Phytochemistry Reviews, 17(1), 161-194.

Housley, L., Magana, A. A., Hsu, A., Beaver, L. M., Wong, C. P., Stevens, J. F., Choi, J., Jiang, Y., Bella, D., Williams, D. E., Maier, C. S., Shannon, J., Dashwood, R. H., & Ho, E. (2018). Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts. Mol Nutr Food Res. PMCID: PMC6310001

Kubglomsong, S., Theerakulkait, C., Reed, R. L., Yang, L., Maier, C. S., & Stevens, J. F. (2018). Isolation and Identification of Tyrosinase-Inhibitory and Copper-Chelating Peptides from Hydrolyzed Rice-Bran-Derived Albumin. J Agric Food Chem, 66(31), 8346-8354. PMID: 30016586

Li, X., & Carter, R. G. (2018a). Pummerer Cyclization Revisited: Unraveling of Acyl Oxonium Ion and Vinyl Sulfide Pathways. Org Lett, 20(18), 5541-5545. PMID: 30199264

Li, X., & Carter, R. G. (2018b). Total Syntheses of Aromatic Abietane Diterpenoids Utilizing Advances in the Pummerer Rearrangement. Org Lett, 20(18), 5546-5549. PMID: 30199260

Miranda, C. L., Johnson, L. A., de Montgolfier, O., Elias, V. D., Ullrich, L. S., Hay, J. J., Paraiso, I. L., Choi, J., Reed, R. L., Revel, J. S., Kioussi, C., Bobe, G., Iwaniec, U. T., Turner, R. T., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Blakemore, P. R., Gombart, A. F., Maier, C. S., Raber, J., & Stevens, J. F. (2018). Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice. Sci Rep, 8(1), 613. PMCID: PMC5766630

Nielsen, S. D., Beverly, R. L., & Dallas, D. C. (2018). Milk Proteins Are Predigested Within the Human Mammary Gland. J Mammary Gland Biol Neoplasia. PMCID: PMC5856648

Nielsen, S. D., Beverly, R. L., Underwood, M. A., & Dallas, D. C. (2018). Release of functional peptides from mother's milk and fortifier proteins in the premature infant stomach. PLoS One, 13(11), e0208204. PMCID: PMC6264471

O'Connor, A., Konda, V., Reed, R. L., Christensen, J. M., Stevens, J. F., & Contractor, N. (2018). Rice Protein Matrix Enhances Circulating Levels of Xanthohumol Following Acute Oral Intake of Spent Hops in Humans. Mol Nutr Food Res. PMID: 29322620

Rewerts, J. N., Morre, J. T., Simonich, S. L. M., & Field, J. A. (2018). In-Vial Extraction Large Volume Gas Chromatography Mass Spectrometry for Analysis of Volatile PFASs on Papers and Textiles. Environ Sci Technol, 52(18), 10609-10616. PMID: 30148348

Selamassakul, O., Laohakunjit, N., Kerdchoechuen, O., Yang, L. P., & Maier, C. S. (2018). Isolation and characterisation of antioxidative peptides from bromelain-hydrolysed brown rice protein by proteomic technique. Process Biochemistry, 70, 179-187.

Yang, L., Hernandez, R. V., Tran, T. N., Nirudodhi, S., Beck, W. H. J., Maier, C. S., & Narayanaswami, V. (2018). Ordered opening of LDL receptor binding domain of human apolipoprotein E3 revealed by hydrogen/deuterium exchange mass spectrometry and fluorescence spectroscopy. Biochim Biophys Acta Proteins Proteom, 1866(11), 1165-1173. PMID: 30282614

Zandkarimi, F., Vanegas, J., Fern, X., Maier, C. S., & Bobe, G. (2018). Metabotypes with elevated protein and lipid catabolism and inflammation precede clinical mastitis in prepartal transition dairy cows. J Dairy Sci, 101(6), 5531-5548. PMID: 29573799

Zhang, Y., Wong, C. P., Gallo, R. L., Gamboa, A. R., Olson, D. A., Lowry, M. B., Fantacone, M. L., Maier, C. S., Stevens, J. F., Turner, R. T., Iwaniec, U. T., & Gombart, A. F. (2018). Knockout and Human Transgenie Mouse Models Reveal a Role for the Cathelicidin Antimicrobial Peptide (Camp/CAMP) Gene in Bone Metabolism. Journal of Bone and Mineral Research, 33, 351-351.

Mass Spectrometry Center Publications_2017

Barker, J. E., Frederickson, C. K., Jones, M. H., Zakharov, L. N., & Haley, M. M. (2017). Synthesis and Properties of Quinoidal Fluorenofluorenes. Org Lett, 19(19), 5312-5315. PMID: 28901775

Barzen-Hanson, K. A., Roberts, S. C., Choyke, S., Oetjen, K., McAlees, A., Riddell, N., McCrindle, R., Ferguson, P. L., Higgins, C. P., & Field, J. A. (2017). Discovery of 40 Classes of Per- and Polyfluoroalkyl Substances in Historical Aqueous Film-Forming Foams (AFFFs) and AFFF-Impacted Groundwater. Environ Sci Technol, 51(4), 2047-2057. PMID: 28098989

Chibwe, L., Davie-Martin, C. L., Aitken, M. D., Hoh, E., & Massey Simonich, S. L. (2017). Identification of polar transformation products and high molecular weight polycyclic aromatic hydrocarbons (PAHs) in contaminated soil following bioremediation. Sci Total Environ, 599-600, 1099-1107. PMID: 28511355

DenHerder, J. M., Reed, R. L., Sargent, J. L., Bobe, G., Stevens, J. F., & Diggs, H. E. (2017). Effects of Time and Storage Conditions on the Chemical and Microbiologic Stability of Diluted Buprenorphine for Injection. J Am Assoc Lab Anim Sci, 56(4), 457-461. PMCID: PMC5517336

Dressler, J. J., Zhou, Z., Marshall, J. L., Kishi, R., Takamuku, S., Wei, Z., Spisak, S. N., Nakano, M., Petrukhina, M. A., & Haley, M. M. (2017). Synthesis of the Unknown Indeno[1,2-a]fluorene Regioisomer: Crystallographic Characterization of Its Dianion. Angew Chem Int Ed Engl. PMID: 28985444

Ellinwood, D. C., El-Mansy, M. F., Plagmann, L. S., Stevens, J. F., Maier, C. S., Gombart, A. F., & Blakemore, P. R. (2017). Total Synthesis of [13 C]2 -, [13 C]3 -, and [13 C]5 -Isotopomers of Xanthohumol, the Principal Prenylflavonoid From Hops. J Labelled Comp Radiopharm. 60(14):639-648. PMCID: PMC5832448

Eytel, L. M., Gilbert, A. K., Gorner, P., Zakharov, L. N., Johnson, D. W., & Haley, M. M. (2017). Do CH-Anion and Anion-pi Interactions Alter the Mechanism of 2:1 Host-Guest Complexation in Arylethynyl Monourea Anion Receptors? Chemistry, 23(17), 4051-4054. PMCID: PMC5560113

Johnson, L. A., Torres, E. R., Impey, S., Stevens, J. F., & Raber, J. (2017). Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome. Sci Rep, 7, 43701. PMCID: PMC5341123

Li, S., Teegarden, A., Bauer, E. M., Choi, J., Messaddeq, N., Hendrix, D. A., Ganguli-Indra, G., Leid, M., & Indra, A. K. (2017). Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep, 7(1), 13427. PMCID: PMC5647389

McDougall, M., Choi, J., Kim, H. K., Bobe, G., Stevens, J. F., Cadenas, E., Tanguay, R., & Traber, M. G. (2017a). Lethal dysregulation of energy metabolism during embryonic vitamin E deficiency. Free Radic Biol Med, 104, 324-332. PMCID: PMC5344700

McDougall, M., Choi, J., Kim, H. K., Bobe, G., Stevens, J. F., Cadenas, E., Tanguay, R., & Traber, M. G. (2017b). Lipid quantitation and metabolomics data from vitamin E-deficient and -sufficient zebrafish embryos from 0 to 120 hours-post-fertilization. Data Brief, 11, 432-441. PMCID: PMC5334496

McDougall, M., Choi, J., Magnusson, K., Truong, L., Tanguay, R., & Traber, M. G. (2017). Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism. Free Radic Biol Med, 112, 308-317. PMCID: PMC5629005

McDougall, M., Choi, J., Truong, L., Tanguay, R., & Traber, M. G. (2017). Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets. Free Radic Biol Med, 110, 250-260. PMCID: PMC5548191

Mellbye, B. L., Spieck, E., Bottomley, P. J., & Sayavedra-Soto, L. A. (2017). Acyl-Homoserine Lactone Production in Nitrifying Bacteria of the Genera Nitrosospira, Nitrobacter, and Nitrospira Identified via a Survey of Putative Quorum-Sensing Genes. Appl Environ Microbiol. 2017 Oct 31;83(22) PMCID: PMC5666142

Mukherjee, S., Kapp, E. A., Lothian, A., Roberts, A. M., Vasil'ev, Y. V., Boughton, B. A., Barnham, K. J., Kok, W. M., Hutton, C. A., Masters, C. L., Bush, A. I., Beckman, J. S., Dey, S. G., & Roberts, B. R. (2017). Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry. Analytical Chemistry, 89(11), 6136-6145. PMID: 28453255

Nielsen, S. D., Beverly, R. L., & Dallas, D. C. (2017). Peptides Released from Foremilk and Hindmilk Proteins by Breast Milk Proteases Are Highly Similar. Front Nutr, 4, 54. PMCID: PMC5673630

Perkins, M. J., Joye, S. B., & Field, J. A. (2017). Selective quantification of DOSS in marine sediment and sediment-trap solids by LC-QTOF-MS. Anal Bioanal Chem, 409(4), 971-978. PMID: 27888309

Poothong, S., Morre, J., Maier, C. S., & Reed, B. M. (2017). Metabolic changes and improved growth in micropropagated red raspberry "Indian summer" are tied to improved mineral nutrition. In Vitro Cellular & Developmental Biology-Plant, 53(6), 579-590.

Stevens, J. F., Revel, J. S., & Maier, C. S. (2017). Mitochondria-centric Review of Polyphenol Bioactivity in Cancer Models. Antioxid Redox Signal. PMCID: PMC6207154

Tresca, B. W., Brueckner, A. C., Haley, M. M., Cheong, P. H., & Johnson, D. W. (2017). Computational and Experimental Evidence of Emergent Equilibrium Isotope Effects in Anion Receptor Complexes. J Am Chem Soc, 139(11), 3962-3965. PMCID: PMC5364433

Troyer, R. M., Ruby, C. E., Goodall, C. P., Yang, L., Maier, C. S., Albarqi, H. A., Brady, J. V., Bathke, K., Taratula, O., Mourich, D., & Bracha, S. (2017). Exosomes from Osteosarcoma and normal osteoblast differ in proteomic cargo and immunomodulatory effects on T cells. Exp Cell Res. PMID: 28712929

Mass Spectrometry Center Publications_2016

Brown, N. M., Mueller, R. S., Shepardson, J. W., Landry, Z. C., Morre, J. T., Maier, C. S., Hardy, F. J., & Dreher, T. W. (2016). Structural and functional analysis of the finished genome of the recently isolated toxic Anabaena sp. WA102. BMC Genomics, 17(1), 457. PMCID: PMC4907049

Chinison, J. J., Danelishvili, L., Gupta, R., Rose, S. J., Babrak, L. M., & Bermudez, L. E. (2016). Identification of Mycobacterium avium subsp. hominissuis secreted proteins using an in vitro system mimicking the phagosomal environment. BMC Microbiol, 16(1), 270. PMCID: PMC5103417

Fabilane, C. S., Nguyen, P. N., Hernandez, R. V., Nirudodhi, S., Duong, M., Maier, C. S., & Narayanaswami, V. (2016). Mechanism of Lipid Binding of Human Apolipoprotein E3 by Hydrogen/Deuterium Exchange/Mass Spectrometry and Fluorescence Polarization. Protein Pept Lett, 23(4), 404-413. PMID: 26902251

Hammers, M. D., Singh, L., Montoya, L. A., Moghaddam, A. D., & Pluth, M. D. (2016). Synthesis of Amino-ADT Provides Access to Hydrolytically Stable Amide-Coupled Hydrogen Sulfide Releasing Drug Targets. Synlett, 27(9), 1349-1353. PMCID: PMC4936786

Huang, L., Wickramasekara, S. I., Akinyeke, T., Stewart, B. S., Jiang, Y., Raber, J., & Maier, C. S. (2016). Ion mobility-enhanced MS(E)-based label-free analysis reveals effects of low-dose radiation post contextual fear conditioning training on the mouse hippocampal proteome. J Proteomics, 140, 24-36. PMCID: PMC5029422

J. L. Marshall, K. U., C. K. Frederickson, C. Schütt, A. M. Zeidell, K. P. Goetz, T. W. Finn, K. Jarolimek, L. N. Zakharov, C. Risko, R. Herges, O. D. Jurchescu and M. M. Haley. (2016). Indacenodibenzothiophenes: Synthesis, Optoelectronic Properties and Materials Applications of Molecules with Strong Antiaromatic Character. Chem. Sci., 7, 5547-5558. PMCID: PMC5207214

Johnson, L. A., Zuloaga, K. L., Kugelman, T. L., Mader, K. S., Morre, J. T., Zuloaga, D. G., Weber, S., Marzulla, T., Mulford, A., Button, D., Lindner, J. R., Alkayed, N. J., Stevens, J. F., & Raber, J. (2016). Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma. EBioMedicine, 3, 26-42. PMCID: PMC4739422

Kang, J. Y., Johnston, R. C., Snyder, K. M., Cheong, P. H., & Carter, R. G. (2016). Construction of Stereogenic alpha,alpha-Disubstituted Cycloalkanones via 1 degrees Amine Thiourea Dual Catalysis: Experimental Scope and Computational Analyses. J Org Chem, 81(9), 3629-3637. PMID: 27095132

Kirkwood, J. S., Miranda, C. L., Bobe, G., Maier, C. S., & Stevens, J. F. (2016). 18O-Tracer Metabolomics Reveals Protein Turnover and CDP-Choline Cycle Activity in Differentiating 3T3-L1 Pre-Adipocytes. PLoS One, 11(6), e0157118. PMCID: PMC4898700

Kuhn, N., Serrano, A., Abello, C., Arce, A., Espinoza, C., Gouthu, S., Deluc, L., & Arce-Johnson, P. (2016). Regulation of polar auxin transport in grapevine fruitlets (Vitis vinifera L.) and the proposed role of auxin homeostasis during fruit abscission. BMC Plant Biol, 16(1), 234. PMCID: PMC5084367

Marshall, J. L., O'Neal, N. J., Zakharov, L. N., & Haley, M. M. (2016). Synthesis and Characterization of Two Unsymmetrical Indenofluorene Analogues: Benzo[5,6]-s-indaceno[1,2-b]thiophene and Benzo[5,6]-s-indaceno[2,1-b]thiophene. J Org Chem, 81(9), 3674-3680. PMID: 27014864

McDougall, M. Q., Choi, J., Stevens, J. F., Truong, L., Tanguay, R. L., & Traber, M. G. (2016). Lipidomics and H2(18)O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in alpha-tocopherol deficient zebrafish (danio rerio) embryos. Redox Biol, 8, 165-174. PMCID: PMC4732018

Miranda, C. L., Elias, V. D., Hay, J. J., Choi, J., Reed, R. L., & Stevens, J. F. (2016). Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice. Arch Biochem Biophys, 599, 22-30. PMCID: PMC4875845

Mohamed F. EI-Mansy, J. Y. K., Rajinikanth Lingampally, Rich G. Carter. (2016). Proline Sulfonamide-Catalyzed, Domino Process for Asymmetric Synthesis of Amino- and Hydroxy-Substituted Bicyclo[2.2.2]octanes. Eur. J. Org. Chem. 150-157

Rose, S. J., & Bermudez, L. E. (2016). Identification of Bicarbonate as a Trigger and Genes Involved with Extracellular DNA Export in Mycobacterial Biofilms. MBio, 7(6). PMCID: PMC5142616

Rudebusch, G. E., Zafra, J. L., Jorner, K., Fukuda, K., Marshall, J. L., Arrechea-Marcos, I., Espejo, G. L., Ponce Ortiz, R., Gomez-Garcia, C. J., Zakharov, L. N., Nakano, M., Ottosson, H., Casado, J., & Haley, M. M. (2016). Diindeno-fusion of an anthracene as a design strategy for stable organic biradicals. Nat Chem, 8(8), 753-759. PMID: 27442280

Saha, M., Li, X., Collett, N. D., & Carter, R. G. (2016). Unified Synthesis of 10-Oxygenated Lycopodium Alkaloids: Impact of C10-Stereochemistry on Reactivity. J Org Chem, 81(14), 5963-5980. PMID: 27353498

Stevens, J. F., & Maier, C. S. (2016). The Chemistry of Gut Microbial Metabolism of Polyphenols. Phytochem Rev, 15(3), 425-444.

Tresca, B. W., Berryman, O. B., Zakharov, L. N., Johnson, D. W., & Haley, M. M. (2016). Anion-directed self-assembly of a 2,6-bis(2-anilinoethynyl)pyridine bis(amide) scaffold. Supramol Chem, 28(1-2), 37-44. PMCID: PMC4838391

Tzeng, S. C., & Maier, C. S. (2016). Label-Free Proteomics Assisted by Affinity Enrichment for Elucidating the Chemical Reactivity of the Liver Mitochondrial Proteome toward Adduction by the Lipid Electrophile 4-hydroxy-2-nonenal (HNE). Front Chem, 4, 2. PMCID: PMC4865762

Vonnegut, C. L., Shonkwiler, A. M., Zakharov, L. N., Haley, M. M., & Johnson, D. W. (2016). Harnessing solid-state packing for selective detection of chloride in a macrocyclic anionophore. Chem Commun (Camb), 52(61), 9506-9509. PMCID: PMC4973467

Watson, G. W., Wickramasekara, S., Fang, Y., Maier, C. S., Williams, D. E., Dashwood, R. H., Perez, V. I., & Ho, E. (2015). HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. Exp Biol Med(Maywood). 241(11): 1177-85 PMCID: PMC4950308

Watanabe, K., Li, J., Veerasamy, N., Ghosh, A., & Carter, R. G. (2016). Stereoselective, Ag-Catalyzed Cyclizations To Access Polysubstituted Pyran Ring Systems: Synthesis of C1-C12 Subunit of Madeirolide A. Org Lett, 18(8), 1744-1747. PMID: 27031993

Wattanasiritham, L., Theerakulkait, C., Wickramasekara, S., Maier, C. S., & Stevens, J. F. (2016). Isolation and identification of antioxidant peptides from enzymatically hydrolyzed rice bran protein. Food Chem, 192, 156-162. PMID: 26304333

Mass Spectrometry Center Publications_2015

Atwell, L. L., Hsu, A., Wong, C. P., Stevens, J. F., Bella, D., Yu, T. W., Pereira, C. B., Lohr, C. V., Christensen, J. M., Dashwood, R. H., Williams, D. E., Shannon, J., & Ho, E. (2015). Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res, 59(3), 424-433. PMCID: PMC4394840

Axton, E. R., Hardardt, E. A., & Stevens, J. F. (2015). Stable isotope-assisted LC-MS/MS monitoring of glyceryl trinitrate bioactivation in a cell culture model of nitrate tolerance. J Chromatogr B Analyt Technol Biomed Life Sci. PMCID: PMC4909631

Babrak, L., Danelishvili, L., Rose, S. J., & Bermudez, L. E. (2015). Microaggregate-associated protein involved in invasion of epithelial cells by Mycobacterium avium subsp. hominissuis. Virulence, 6(7), 694-703. PMCID: PMC4720229

Babrak, L., Danelishvili, L., Rose, S. J., Kornberg, T., & Bermudez, L. E. (2015). The environment of "Mycobacterium avium subsp. hominissuis" microaggregates induces synthesis of small proteins associated with efficient infection of respiratory epithelial cells. Infect Immun, 83(2), 625-636. PMCID: PMC4294266

Bailey, T. S., & Pluth, M. D. (2015). Reactions of isolated persulfides provide insights into the interplay between H2S and persulfide reactivity. Free Radic Biol Med, 89, 662-667. PMCID: PMC4684792

Berryman, O. B., Johnson, C. A., 2nd, Vonnegut, C. L., Fajardo, K. A., Zakharov, L. N., Johnson, D. W., & Haley, M. M. (2015). Solid-State Examination of Conformationally Diverse Sulfonamide Receptors Based on Bis(2-anilinoethynyl)pyridine, -Bipyridine, and -Thiophene. Cryst Growth Des, 15(3), 1502-1511. PMCID: PMC4577069

Choi, J., Leonard, S. W., Kasper, K., McDougall, M., Stevens, J. F., Tanguay, R. L., & Traber, M. G. (2015). Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. J Lipid Res, 56(6), 1182-1190. PMCID: PMC4442875

Diaz-Gonzalez, F., Milano, M., Olguin-Araneda, V., Pizarro-Cerda, J., Castro-Cordova, P., Tzeng, S. C., Maier, C. S., Sarker, M. R., & Paredes-Sabja, D. (2015). Protein composition of the outermost exosporium-like layer of Clostridium difficile 630 spores. J Proteomics, 123, 1-13. PMID: 25849250

Elie, M. R., Choi, J., Nkrumah-Elie, Y. M., Gonnerman, G. D., Stevens, J. F., & Tanguay, R. L. (2015). Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish. Environ Res, 140, 502-510. PMCID: PMC4492807

Hammers, M. D., Taormina, M. J., Cerda, M. M., Montoya, L. A., Seidenkranz, D. T., Parthasarathy, R., & Pluth, M. D. (2015). A Bright Fluorescent Probe for H2S Enables Analyte-Responsive, 3D Imaging in Live Zebrafish Using Light Sheet Fluorescence Microscopy. J Am Chem Soc, 137(32), 10216-10223. PMCID: PMC4543995

Harper, T. A., Jr., Morre, J., Lauer, F. T., McQuistan, T. J., Hummel, J. M., Burchiel, S. W., & Williams, D. E. (2015). Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS. Mutat Res Genet Toxicol Environ Mutagen, 782, 51-56. PMCID: PMC4395865

J. L. Marshall, G. E. R., L. N. Zakharov and M. M. Haley. (2015). Synthesis and Properties of Fully Conjugated Indacenediselenophene and Diindenoselenophene Derivatives. Tetrahedron Lett., 56, 3235-3239.

Khalifa, M. M., Bodner, M. J., Berglund, J. A., & Haley, M. M. (2015). Synthesis of N-substituted aryl amidines by strong base activation of amines. Tetrahedron Lett, 56(27), 4109-4111. PMCID: PMC4470429

Montezano, D., Meek, L., Gupta, R., Bermudez, L. E., & Bermudez, J. C. (2015). Flux Balance Analysis with Objective Function Defined by Proteomics Data-Metabolism of Mycobacterium tuberculosis Exposed to Mefloquine. PLoS One, 10(7), e0134014. PMCID: PMC4517854

Montoya, L. A., Shen, X., McDermott, J. J., Kevil, C. G., & Pluth, M. D. (2015). Mechanistic investigations reveal that dibromobimane extrudes sulfur from biological sulfhydryl sources other than hydrogen sulfidedaggerElectronic supplementary information (ESI) available: Experimental details, pH stability data for BTE, NMR spectra. See DOI: 10.1039/c4sc01875cClick here for additional data file. Chem Sci, 6(1), 294-300. PMCID: PMC4302847

Roemeling, M. D., Williams, J., Beckman, J. S., & Hurst, J. K. (2015). Imidazole catalyzes chlorination by unreactive primary chloramines. Free Radic Biol Med, 82, 167-178. PMCID: PMC4387080

Siboni, R. B., Bodner, M. J., Khalifa, M. M., Docter, A. G., Choi, J. Y., Nakamori, M., Haley, M. M., & Berglund, J. A. (2015). Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models. J Med Chem, 58(15), 5770-5780. PMCID: PMC4972181

Sommer, S. K., Henle, E. A., Zakharov, L. N., & Pluth, M. D. (2015). Selection for a Single Self-Assembled Macrocycle from a Hybrid Metal-Ligand Hydrogen-Bonded (MLHB) Ligand Subunit. Inorg Chem, 54(14), 6910-6916. PMID: 26146881

Sommer, S. K., Zakharov, L. N., & Pluth, M. D. (2015). Design, synthesis, and characterization of hybrid metal-ligand hydrogen-bonded (MLHB) supramolecular architectures. Inorg Chem, 54(4), 1912-1918. PMID: 25611134

Tresca, B. W., Hansen, R. J., Chau, C. V., Hay, B. P., Zakharov, L. N., Haley, M. M., & Johnson, D. W. (2015). Substituent Effects in CH Hydrogen Bond Interactions: Linear Free Energy Relationships and Influence of Anions. J Am Chem Soc, 137(47), 14959-14967. PMCID: PMC4977030

Vining, O. B., Medina, R. A., Mitchell, E. A., Videau, P., Li, D., Serrill, J. D., Kelly, J. X., Gerwick, W. H., Proteau, P. J., Ishmael, J. E., & McPhail, K. L. (2015). Depsipeptide companeramides from a Panamanian marine cyanobacterium associated with the coibamide producer. J Nat Prod, 78(3), 413-420. PMCID:


Voinov, V. G., Hoffman, P. D., Bennett, S. E., Beckman, J. S., & Barofsky, D. F. (2015). Electron Capture Dissociation of Sodium-Adducted Peptides on a Modified Quadrupole/Time-of-Flight Mass Spectrometer. J Am Soc Mass Spectrom, 26(12), 2096-2104. PMID: 26266643

Vonnegut, C. L., Shonkwiler, A. M., Khalifa, M. M., Zakharov, L. N., Johnson, D. W., & Haley, M. M. (2015). Facile Synthesis and Properties of 2-lambda(5)-Phosphaquinolines and 2-lambda(5)-Phosphaquinolin-2-ones. Angew Chem Int Ed Engl, 54(45), 13318-13322. PMCID: PMC4624000

Wang, X., Chandrabose, R. S., Chun, S. E., Zhang, T., Evanko, B., Jian, Z., Boettcher, S. W., Stucky, G. D., & Ji, X. (2015). High Energy Density Aqueous Electrochemical Capacitors with a KI-KOH Electrolyte. ACS Appl Mater Interfaces, 7(36), 19978-19985. PMID: 26310453

Watson, G. W., Wickramasekara, S., Fang, Y., Palomera-Sanchez, Z., Maier, C. S., Williams, D. E., Dashwood, R. H., Perez, V. I., & Ho, E. (2015). Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells. Mol Nutr Food Res, 59(10), 1954-1961. PMCID: PMC4651621

Watson, G. W., Wickramasekara, S., Maier, C. S., Williams, D. E., Dashwood, R. H., & Ho, E. (2015). Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure. EuPA Open Proteom, 9, 34-40. PMCID: PMC4666544

Mass Spectrometry Center Publications_2014

Alwedi, E. Z., L. N.; Blakemore, P. R. (2014). Chain Extension of Boronic Esters with Lithiooxiranes Generated by Sulfoxide-Metal Exchange: Stereocontrolled Access to 2°/2°, 2°/3°, and 3°/3° Vicinal Diols and Related Compounds. Eur. J. Org. Chem., 6643-6648.

Bailey, T. S., Zakharov, L. N., & Pluth, M. D. (2014). Understanding hydrogen sulfide storage: probing conditions for sulfide release from hydrodisulfides. J Am Chem Soc, 136(30), 10573-10576. PMCID: PMC4120993

Barsamian, A. L., Perkins, M. J., Field, J. A., & Blakemore, P. R. (2014). Regioselective syntheses of [13C]4-labelled sodium 1-carboxy-2-(2-ethylhexyloxycarbonyl)ethanesulfonate and sodium 2-carboxy-1-(2-ethylhexyloxycarbonyl)ethanesulfonate from [13C]4-maleic anhydride. J Labelled Comp Radiopharm, 57(5), 397-401. PMCID: PMC4167582

Bracha, S., McNamara, M., Hilgart, I., Milovancev, M., Medlock, J., Goodall, C., Wickramasekara, S., & Maier, C. S. (2014). A multiplex biomarker approach for the diagnosis of transitional cell carcinoma from canine urine. Anal Biochem, 455, 41-47. PMCID: PMC4874471

Carini, P., Campbell, E. O., Morre, J., Sanudo-Wilhelmy, S. A., Thrash, J. C., Bennett, S. E., Temperton, B., Begley, T., & Giovannoni, S. J. (2014). Discovery of a SAR11 growth requirement for thiamin's pyrimidine precursor and its distribution in the Sargasso Sea. ISME J, 8(8), 1727-1738. PMCID: PMC4817611

Duesterdieck-Zellmer, K. F., Moneta, L., Ott, J. F., Larson, M. K., Gorman, E. M., Hunter, B., Lohr, C. V., Payton, M. E., Morre, J. T., & Maier, C. S. (2014). Effects of low and high dose intraarticular tiludronate on synovial fluid and clinical variables in healthy horses-a preliminary investigation. PeerJ, 2, e534. PMCID: PMC4157236

Engle, J. M., Singh, P. S., Vonnegut, C. L., Zakharov, L. N., Johnson, D. W., & Haley, M. M. (2014). Synthesis and solid-state structures of a macrocyclic receptor based on the 2,6-bis(2-anilinoethynyl)pyridine scaffold. CrystEngComm, 16(18), 3703-3706. PMCID: PMC4284647

Farley, S. M., Leonard, S. W., Stevens, J. F., & Traber, M. G. (2014). Deuterium-labeled phylloquinone fed to alpha-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion. Mol Nutr Food Res, 58(8), 1610-1619. PMCID: PMC4183557

Frederickson, C. K., & Haley, M. M. (2014). Synthesis and optoelectronic properties of indeno[1,2-b]fluorene-6,12-dione donor-acceptor-donor triads. J Org Chem, 79(22), 11241-11245. PMID: 25329864

G.E. Rudebusch, A. G. F., H.A. Henthorn, C.L. Vonnegut, L.N. Zakharov and M.M. Haley. (2014). Quinoidal Diindenothienoacenes: Synthesis and Properties of New Functional Organic Materials. Chem. Sci., 5, 3627-3633.

Gray, N. E., Morre, J., Kelley, J., Maier, C. S., Stevens, J. F., Quinn, J. F., & Soumyanath, A. (2014). Caffeoylquinic acids in Centella asiatica protect against amyloid-beta toxicity. J Alzheimers Dis, 40(2), 359-373. PMCID: PMC3973491

Hammers, M. D., & Pluth, M. D. (2014). Ratiometric measurement of hydrogen sulfide and cysteine/homocysteine ratios using a dual-fluorophore fragmentation strategy. Analytical Chemistry, 86(14), 7135-7140. PMCID: PMC4100788

Henderson, M. C., Siddens, L. K., Krueger, S. K., Stevens, J. F., Kedzie, K., Fang, W. K., Heidelbaugh, T., Nguyen, P., Chow, K., Garst, M., Gil, D., & Williams, D. E. (2014). Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones. Toxicol Appl Pharmacol, 278(2), 91-99. PMCID: PMC4110205

Intanon, S., Reed, R. L., Stevens, J. F., Hulting, A. G., & Mallory-Smith, C. A. (2014). Identification and phytotoxicity of a new glucosinolate breakdown product from Meadowfoam (Limnanthes alba) seed meal. J Agric Food Chem, 62(30), 7423-7429. PMID: 24998843

Legette, L., Karnpracha, C., Reed, R. L., Choi, J., Bobe, G., Christensen, J. M., Rodriguez-Proteau, R., Purnell, J. Q., & Stevens, J. F. (2014). Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res, 58(2), 248-255. PMCID: PMC4371792

Luo, W., Wang, B., Heron, C. G., Allen, M. J., Morre, J., Maier, C. S., Stickle, W. F., & Ji, X. (2014). Pyrolysis of cellulose under ammonia leads to nitrogen-doped nanoporous carbon generated through methane formation. Nano Lett, 14(4), 2225-2229. PMID: 24679142

Martha Rosales-Castro1, R. F. G.-L., Young-Soo Bae, Jin Kgu Kim, Jeff Morre, and Joseph J. Karchesy. . (2014). Characterization and Antioxidant Properties of the Condensed Tannins from Alaska Cedar Inner Bark. Rec. Nat. Prod., 8(3), 217-227.

McGrath, J. M., & Pluth, M. D. (2014a). Linear free energy relationships reveal structural changes in hydrogen-bonded host-guest interactions. J Org Chem, 79(23), 11797-11801. PMCID: PMC4260963

McGrath, J. M., & Pluth, M. D. (2014b). Understanding the effects of preorganization, rigidity, and steric interactions in synthetic barbiturate receptors. J Org Chem, 79(2), 711-719. PMCID: PMC4002384

Minato, Y., Fassio, S. R., Kirkwood, J. S., Halang, P., Quinn, M. J., Faulkner, W. J., Aagesen, A. M., Steuber, J., Stevens, J. F., & Hase, C. C. (2014). Roles of the sodium-translocating NADH:quinone oxidoreductase (Na+-NQR) on vibrio cholerae metabolism, motility and osmotic stress resistance. PLoS One, 9(5), e97083. PMCID: PMC4014592

Montoya, L. A., & Pluth, M. D. (2014). Hydrogen sulfide deactivates common nitrobenzofurazan-based fluorescent thiol labeling reagents. Analytical Chemistry, 86(12), 6032-6039. PMCID: PMC4063329

Motorykin, I., Traber, M. G., Tanguay, R. L., & Maier, C. S. (2014). Proteome-driven elucidation of adaptive responses to combined vitamin E and C deficiency in zebrafish. J Proteome Res, 13(3), 1647-1656. PMCID: PMC3993953

Vasil'ev, Y. V., Tzeng, S. C., Huang, L., & Maier, C. S. (2014). Protein modifications by electrophilic lipoxidation products: adduct formation, chemical strategies and tandem mass spectrometry for their detection and identification. Mass Spectrom Rev, 33(3), 157-182. PMCID: PMC4138024

Vincenzi, S., Bierma, J., Wickramasekara, S. I., Curioni, A., Gazzola, D., & Bakalinsky, A. T. (2014). Characterization of a grape class IV chitinase. J Agric Food Chem, 62(24), 5660-5668. PMCID: PMC4216234

Voinov, V. G., Bennett, S. E., Beckman, J. S., & Barofsky, D. F. (2014). ECD of tyrosine phosphorylation in a triple quadrupole mass spectrometer with a radio-frequency-free electromagnetostatic cell. J Am Soc Mass Spectrom, 25(10), 1730-1738. PMCID: PMC4163116

Watson, G. W., Wickramasekara, S., Palomera-Sanchez, Z., Black, C., Maier, C. S., Williams, D. E., Dashwood, R. H., & Ho, E. (2014). SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells. Oncogenesis, 3, e131. PMCID: PMC4275561

Yang, L., Broderick, D., Jiang, Y., Hsu, V., & Maier, C. S. (2014). Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone. Biochim Biophys Acta, 1844(9), 1684-1693. PMCID: PMC4137978

Young, B. S., Chase, D. T., Marshall, J. L., Vonnegut, C. L., Zakharov, L. N., & Haley, M. M. (2014). Synthesis and Properties of Fully-Conjugated Indacenedithiophenes. Chem Sci, 5(3), 1008-1014. PMCID: PMC3979547

Zamzow, D. R., Elias, V., Legette, L. L., Choi, J., Stevens, J. F., & Magnusson, K. R. (2014). Xanthohumol improved cognitive flexibility in young mice. Behav Brain Res, 275, 1-10. PMCID: PMC4281268

Mass Spectrometry Center Publications_2013

Chimploy, K., Song, S., Wheeler, L. J., & Mathews, C. K. (2013). Ribonucleotide reductase association with mammalian liver mitochondria. J Biol Chem, 288(18), 13145-13155. PMCID: PMC3642355

Deluc, S. G. M. S. M. G. (2013). An Analytical Method to Quantify Three Plant Hormone Families in Grape Berry Using Liquid Chromatography and Multiple Reaction Monitoring Mass Spectrometry. Recent Advances in Phytochemistry, 42, 19-36.

Eaton, H. L., Duringer, J. M., Murty, L. D., & Craig, A. M. (2013). Anaerobic bioremediation of RDX by ovine whole rumen fluid and pure culture isolates. Appl Microbiol Biotechnol, 97(8), 3699-3710. PMID: 22688904

Emerson, C. R., Zakharov, L. N., & Blakemore, P. R. (2013). Investigation of functionalized alpha-chloroalkyllithiums for a stereospecific reagent-controlled homologation approach to the analgesic alkaloid (-)-epibatidine. Chemistry, 19(48), 16342-16356. PMID: 24127119

Giarrizzo, J. G., Murty, L., Tanaree, D., Walker, K., & Craig, A. M. (2013). Validation of a novel extraction method for studying hexahydro-1,3,5-trinitro-1,3,5 triazine (RDX) biodegradation by ruminal microbiota. J Chromatogr B Analyt Technol Biomed Life Sci, 925, 70-75. PMID: 23523880

Kirkwood, J. S., Legette, L. L., Miranda, C. L., Jiang, Y., & Stevens, J. F. (2013). A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol. J Biol Chem, 288(26), 19000-19013. PMCID: PMC3696674

Kirkwood, J. S., Maier, C., & Stevens, J. F. (2013). Simultaneous, untargeted metabolic profiling of polar and nonpolar metabolites by LC-Q-TOF mass spectrometry. Curr Protoc Toxicol, Chapter 4, Unit4 39. PMCID: PMC3707319

Lebold, K. M., Kirkwood, J. S., Taylor, A. W., Choi, J., Barton, C. L., Miller, G. W., La Du, J., Jump, D. B., Stevens, J. F., Tanguay, R. L., & Traber, M. G. (2013). Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biol, 2, 105-113. PMCID: PMC3887274

Legette, L. L., Luna, A. Y., Reed, R. L., Miranda, C. L., Bobe, G., Proteau, R. R., & Stevens, J. F. (2013). Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats. Phytochemistry, 91, 236-241. PMID: 22640929

Legette, L. L., Reed, R. L., Murty, L., Maier, C. S., & Stevens, J. F. (2013). Application of Paper Strip Extraction in Combination with LC-MS-MS in Pharmacokinetics. Spectroscopy (Springf), 39(10), s18-s25. PMCID: PMC4201118

Lu, L., Zhang, W., Nam, S., Horne, D. A., Jove, R., & Carter, R. G. (2013). Amphidinolide B: total synthesis, structural investigation, and biological evaluation. J Org Chem, 78(6), 2213-2247. PMCID: PMC3631602

Mahapatra, S., & Carter, R. G. (2013). Exploiting hidden symmetry in natural products: total syntheses of amphidinolides C and F. J Am Chem Soc, 135(29), 10792-10803. PMCID: PMC3786714

McNamara, M., Tzeng, S. C., Maier, C., Wu, M., & Bermudez, L. E. (2013). Surface-exposed proteins of pathogenic mycobacteria and the role of cu-zn superoxide dismutase in macrophages and neutrophil survival. Proteome Sci, 11(1), 45. PMCID: PMC4176128

Milovancev, M., Hilgart-Martiszus, I., McNamara, M. J., Goodall, C. P., Seguin, B., Bracha, S., & Wickramasekara, S. I. (2013). Comparative analysis of the surface exposed proteome of two canine osteosarcoma cell lines and normal canine osteoblasts. BMC Vet Res, 9, 116. PMCID: PMC3684535

Rhoads, T. W., Williams, J. R., Lopez, N. I., Morre, J. T., Bradford, C. S., & Beckman, J. S. (2013). Using theoretical protein isotopic distributions to parse small-mass-difference post-translational modifications via mass spectrometry. J Am Soc Mass Spectrom, 24(1), 115-124. PMCID: PMC4119010

Saha, M., & Carter, R. G. (2013). Toward a unified approach for the lycopodines: synthesis of 10-hydroxylycopodine, deacetylpaniculine, and paniculine. Org Lett, 15(4), 736-739. PMCID: PMC3616490

Salih, M. Q., & Beaudry, C. M. (2013). Enantioselective Ullmann ether couplings: syntheses of (-)-myricatomentogenin, (-)-jugcathanin, (+)-galeon, and (+)-pterocarine. Org Lett, 15(17), 4540-4543. PMID: 23947738

Speight, L. C., Muthusamy, A. K., Goldberg, J. M., Warner, J. B., Wissner, R. F., Willi, T. S., Woodman, B. F., Mehl, R. A., & Petersson, E. J. (2013). Efficient synthesis and in vivo incorporation of acridon-2-ylalanine, a fluorescent amino acid for lifetime and Forster resonance energy transfer/luminescence resonance energy transfer studies. J Am Chem Soc, 135(50), 18806-18814. PMCID: PMC4041393

Sun, X., & Blakemore, P. R. (2013). Programmed synthesis of a contiguous stereotriad motif by triple stereospecific reagent-controlled homologation. Org Lett, 15(17), 4500-4503. PMID: 23947788

Thornburg, C. C., Cowley, E. S., Sikorska, J., Shaala, L. A., Ishmael, J. E., Youssef, D. T., & McPhail, K. L. (2013). Apratoxin H and apratoxin A sulfoxide from the Red Sea cyanobacterium Moorea producens. J Nat Prod, 76(9), 1781-1788. PMCID: PMC3969888

Veerasamy, N., Carlson, E. C., Collett, N. D., Saha, M., & Carter, R. G. (2013). Enantioselective approach to quinolizidines: total synthesis of cermizine D and formal syntheses of senepodine G and cermizine C. J Org Chem, 78(10), 4779-4800. PMCID: PMC3711505

Wang, Z., Kirkwood, J. S., Taylor, A. W., Stevens, J. F., Leid, M., Ganguli-Indra, G., & Indra, A. K. (2013). Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. J Invest Dermatol, 133(3), 668-676. PMCID: PMC3556343

Wickramasekara, S. I., Zandkarimi, F., Morre, J., Kirkwood, J., Legette, L., Jiang, Y., Gombart, A. F., Stevens, J. F., & Maier, C. S. (2013). Electrospray Quadrupole Travelling Wave Ion Mobility Time-of-Flight Mass Spectrometry for the Detection of Plasma Metabolome Changes Caused by Xanthohumol in Obese Zucker (fa/fa) Rats. Metabolites, 3(3), 701-717. PMCID: PMC3901285

Zandkarimi, F., Wickramasekara, S., Morre, J., Stevens J. F. and Maier, C. S. (2013). Electrospray ionization traveling wave ion mobility mass spectrometry for the analysis of plant phenolics: An approach for separation of regioisomers. Recent Advances in Phytochemistry, 34, 21-42.

Zhao, P., & Beaudry, C. M. (2013). Total synthesis of (+/-)-cavicularin: control of pyrone Diels-Alder regiochemistry using isomeric vinyl sulfones. Org Lett, 15(2), 402-405. PMID: 23301524

Zhu, Z. Q., & Beaudry, C. M. (2013). Structural revision of garuganin IV and 1,9'-didesmethylgaruganin III through total synthesis. J Org Chem, 78(7), 3336-3341. PMID: 23480215

Zhu, Z. Q., Salih, M. Q., Fynn, E., Bain, A. D., & Beaudry, C. M. (2013). The garuganin and garugamblin diarylether heptanoids: total synthesis and determination of chiral properties using dynamic NMR. J Org Chem, 78(7), 2881-2896. PMID: 23461387

Mass Spectrometry Center Publications_2012

Brewer, A. J., Ort, C., Banta-Green, C. J., Berset, J. D., & Field, J. A. (2012). Normalized diurnal and between-day trends in illicit and legal drug loads that account for changes in population. Environ Sci Technol, 46(15), 8305-8314. PMCID: PMC3462072

Engle, J. M., Carroll, C. N., Johnson, D. W., & Haley, M. M. (2012). Synthesis and optoelectronic properties of 2,6-bis(2-anilinoethynyl)pyridine scaffolds. Chem Sci, 3(4), 1105-1110. PMCID: PMC4201053

Filtz, T. M., Vogel, W. K., Zhang, L. J., Liu, X., Arbogast, B., Zweber, A., Maier, C. S., & Leid, M. (2012). Kinetically differentiated post-translational modifications in a transcription factor, Bcl11b. Faseb Journal, 26.

Gouthu S, S. P., Morré J, Maier CS, Deluc LG. (2012). Berry nitrogen status altered by cover cropping: Effects on berry hormone dynamics, growth and amino acid composition of Pinot Noir. Food Chem, 135, 1-8.

Gouthu S, S. P., Morré J, Maier CS, Deluc LG. (2012). An analytical method to quantify three plant hormone families in grape berry using liquid chromatography and multiple reaction monitoring mass spectrometry. Phytochemicals, Plant Growth, and the Environment. pp 19-36.

Han, B., Hare, M., Wickramasekara, S., Fang, Y., & Maier, C. S. (2012). A comparative 'bottom up' proteomics strategy for the site-specific identification and quantification of protein modifications by electrophilic lipids. J Proteomics, 75(18), 5724-5733. PMCID: PMC3468693

Hernandez, R. V., Dwivedi, P., Patel, A., Nirudodhi, S., Duong, M., Maier, C. S., Venkataraman, A., & Narayanaswami, V. (2012). Structural Analysis of Human Apolipoprotein E3 by Fluorescence Spectroscopy, and Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry. Biophysical Journal, 102(3), 46a-46a.

Jeknic, Z., Morre, J. T., Jeknic, S., Jevremovic, S., Subotic, A., & Chen, T. H. (2012). Cloning and functional characterization of a gene for capsanthin-capsorubin synthase from tiger lily (Lilium lancifolium Thunb. 'Splendens'). Plant and Cell Physiology, 53(11), 1899-1912. PMCID: PMC3494009

Kirkwood, J. S., Lebold, K. M., Miranda, C. L., Wright, C. L., Miller, G. W., Tanguay, R. L., Barton, C. L., Traber, M. G., & Stevens, J. F. (2012). Vitamin C deficiency activates the purine nucleotide cycle in zebrafish. J Biol Chem, 287(6), 3833-3841. PMCID: PMC3281694

Legette, L., Ma, L., Reed, R. L., Miranda, C. L., Christensen, J. M., Rodriguez-Proteau, R., & Stevens, J. F. (2012). Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration. Mol Nutr Food Res, 56(3), 466-474. PMCID: PMC3401605

Lorang, J., Kidarsa, T., Bradford, C. S., Gilbert, B., Curtis, M., Tzeng, S. C., Maier, C. S., & Wolpert, T. J. (2012). Tricking the guard: exploiting plant defense for disease susceptibility. Science, 338(6107), 659-662. PMCID: PMC4125361

Marley, K., Maier, C. S., & Helfand, S. C. (2012). Phosphotyrosine enrichment identifies focal adhesion kinase and other tyrosine kinases for targeting in canine hemangiosarcoma. Vet Comp Oncol, 10(3), 214-222. PMID: 22487216

McNamara, M., Danelishvili, L., & Bermudez, L. E. (2012). The Mycobacterium avium ESX-5 PPE protein, PPE25-MAV, interacts with an ESAT-6 family Protein, MAV_2921, and localizes to the bacterial surface. Microb Pathog, 52(4), 227-238. PMCID: PMC3883564

McNamara, M., Tzeng, S. C., Maier, C., Zhang, L., & Bermudez, L. E. (2012). Surface proteome of "Mycobacterium avium subsp. hominissuis" during the early stages of macrophage infection. Infect Immun, 80(5), 1868-1880. PMCID: PMC3347459

Mellies, J. L., Thomas, K., Turvey, M., Evans, N. R., Crane, J., Boedeker, E., & Benison, G. C. (2012). Zinc-induced envelope stress diminishes type III secretion in enteropathogenic Escherichia coli. BMC Microbiol, 12, 123. PMCID: PMC3438133

Place, B. J., & Field, J. A. (2012). Identification of novel fluorochemicals in aqueous film-forming foams used by the US military. Environ Sci Technol, 46(13), 7120-7127. PMCID: PMC3390017

Trumbull, K. A., McAllister, D., Gandelman, M. M., Fung, W. Y., Lew, T., Brennan, L., Lopez, N., Morre, J., Kalyanaraman, B., & Beckman, J. S. (2012). Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice. Neurobiol Dis, 45(1), 137-144. PMCID: PMC3710723

Zandkarimi, F., Nirudodhi, S., Stevens, J. F., & Maier, C. S. (2012). Plant Phenolics Analysis Using Electrospray Ion Mobility Time-of-Flight Mass Spectrometry. Pharmaceutical Biology, 50(5), 648-648.

Zasada, I. A., Weiland, J. E., Reed, R. L., & Stevens, J. F. (2012). Activity of meadowfoam (Limnanthes alba) seed meal glucolimnanthin degradation products against soilborne pathogens. J Agric Food Chem, 60(1), 339-345. PMCID: PMC4215540

Zhang, L. J., Vogel, W. K., Liu, X., Topark-Ngarm, A., Arbogast, B. L., Maier, C. S., Filtz, T. M., & Leid, M. (2012). Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylation. J Biol Chem, 287(32), 26971-26988. PMCID: PMC3411033

Mass Spectrometry Center Publications_2011

Backe, W. J., Ort, C., Brewer, A. J., & Field, J. A. (2011). Analysis of androgenic steroids in environmental waters by large-volume injection liquid chromatography tandem mass spectrometry. Analytical Chemistry, 83(7), 2622-2630. PMCID: PMC4142814

Chavez, J. D., Wu, J., Bisson, W., & Maier, C. S. (2011). Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction. J Proteomics, 74(11), 2417-2429. PMCID: PMC3199298

Clarke, J., Riedl, K., Bella, D., Schwartz, S., Stevens, J., & Ho, E. (2011). Comparison of the response to broccoli sprouts or broccoli supplement consumption in human subjects. Faseb Journal, 25.

Clarke, J. D., Hsu, A., Yu, Z., Dashwood, R. H., Ho, E. (2011). Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res., 55 (7), 999-1009 PMCID: PMC3129466

Clarke, J. D., Hsu, A., Riedl, K., Bella, D., Schwartz, S. J., Stevens, J. F., & Ho, E. (2011). Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacol Res, 64(5), 456-463. PMCID: PMC3183106

Clarke, J. D., Hsu, A., Williams, D. E., Dashwood, R. H., Stevens, J. F., Yamamoto, M., & Ho, E. (2011). Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res, 28(12), 3171-3179. PMCID: PMC3253624

Clarke, J. D., Riedl, K., Bella, D., Schwartz, S. J., Stevens, J. F., & Ho, E. (2011). Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. J Agric Food Chem, 59(20), 10955-10963.

Dreher, T. W., Brown, N., Bozarth, C. S., Schwartz, A. D., Riscoe, E., Thrash, C., Bennett, S. E., Tzeng, S. C., & Maier, C. S. (2011). A freshwater cyanophage whose genome indicates close relationships to photosynthetic marine cyanomyophages. Environ Microbiol, 13(7), 1858-1874. PMCID: PMC4185292

Forsberg, N. D., Rodriguez-Proteau, R., Ma, L., Morre, J., Christensen, J. M., Maier, C. S., Jenkins, J. J., & Anderson, K. A. (2011). Organophosphorus pesticide degradation product in vitro metabolic stability and time-course uptake and elimination in rats following oral and intravenous dosing. Xenobiotica, 41(5), 422-429. PMCID: PMC3148839

Han, B., Gross, H., McPhail, K. L., Goeger, D., Maier, C. S., & Gerwick, W. H. (2011). Wewakamide A and guineamide G, cyclic depsipeptides from the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula. J Microbiol Biotechnol, 21(9), 930-936. PMID: 21952369

Kuiper, H. C., Bruno, R. S., Traber, M. G., & Stevens, J. F. (2011). Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans. Free Radic Biol Med, 50(7), 848-853. PMCID: PMC3046321

Kuiper, H. C., & Stevens, J. F. (2011). LC-MS/MS quantitation of mercapturic acid conjugates of lipid peroxidation products as markers of oxidative stress. Curr Protoc Toxicol, Chapter 17, Unit17 14 12. PMCID: PMC3062851

Nirudodhi, S., Parsonage, D., Karplus, P. A., Poole, L. B., & Maier, C. S. (2011). Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry. Int J Mass Spectrom, 302(1-3), 93-100. PMCID: PMC3079231

Nyarko, A., & Barbar, E. (2011). Light chain-dependent self-association of dynein intermediate chain. J Biol Chem, 286(2), 1556-1566. PMCID: PMC3020764

Rhoads, T. W., Lopez, N. I., Zollinger, D. R., Morre, J. T., Arbogast, B. L., Maier, C. S., DeNoyer, L., & Beckman, J. S. (2011). Measuring copper and zinc superoxide dismutase from spinal cord tissue using electrospray mass spectrometry. Anal Biochem, 415(1), 52-58. PMCID: PMC3118564

Sowell, S. M., Abraham, P. E., Shah, M., Verberkmoes, N. C., Smith, D. P., Barofsky, D. F., & Giovannoni, S. J. (2011). Environmental proteomics of microbial plankton in a highly productive coastal upwelling system. ISME J, 5(5), 856-865. PMCID: PMC3105774

Traber, M. G., & Stevens, J. F. (2011). Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med, 51(5), 1000-1013. PMCID: PMC3156342

Voinov, V. G., Deinzer, M. L., Beckman, J. S., & Barofsky, D. F. (2011). Electron capture, collision-induced, and electron capture-collision induced dissociation in Q-TOF. J Am Soc Mass Spectrom, 22(4), 607-611. PMCID: PMC4285558

Wang, J., Zhang, J., Arbogast, B., & Maier, C. S. (2011). Tandem mass spectrometric characterization of thiol peptides modified by the chemoselective cationic sulfhydryl reagent (4-iodobutyl)triphenylphosphonium--effects of a cationic thiol derivatization on peptide fragmentation. J Am Soc Mass Spectrom, 22(10), 1771-1783. PMCID: PMC3187551

Wu, J., Stevens, J. F., & Maier, C. S. (2011). Mass spectrometry-based quantification of myocardial protein adducts with acrolein in an in vivo model of oxidative stress. Mol Nutr Food Res, 55(9), 1401-1410. PMCID: PMC3517132

Young, B. S., Kohler, F., Herges, R., & Haley, M. M. (2011). Phenanthrene-fused azo-ene-ynes: synthesis of dibenzo[f,h]cinnoline and dibenzo[e,g]isoindazole derivatives. J Org Chem, 76(20), 8483-8487. PMCID: PMC3888224

Mass Spectrometry Center Publications_2010

Bythell, B. J., Csonka, I. P., Suhai, S., Barofsky, D. F., & Paizs, B. (2010). Gas-phase structure and fragmentation pathways of singly protonated peptides with N-terminal arginine. Journal of Physical Chemistry B, 114(46), 15092-15105. PMCID: PMC3664278

Chavez, J., Chung, W. G., Miranda, C. L., Singhal, M., Stevens, J. F., & Maier, C. S. (2010). Site-specific protein adducts of 4-hydroxy-2(E)-nonenal in human THP-1 monocytic cells: protein carbonylation is diminished by ascorbic acid. Chem Res Toxicol, 23(1), 37-47. PMCID: PMC2825578

Chavez, J. D., Bisson, W. H., & Maier, C. S. (2010). A targeted mass spectrometry-based approach for the identification and characterization of proteins containing alpha-aminoadipic and gamma-glutamic semialdehyde residues. Anal Bioanal Chem, 398(7-8), 2905-2914. PMCID: PMC3071856

Fotso, S., Santosa, D. A., Saraswati, R., Yang, J., Mahmud, T., Zabriskie, T. M., & Proteau, P. J. (2010). Modified phenazines from an Indonesian Streptomyces sp. J Nat Prod, 73(3), 472-475. PMCID: PMC2846220

Gross, H., McPhail, K. L., Goeger, D. E., Valeriote, F. A., & Gerwick, W. H. (2010). Two cytotoxic stereoisomers of malyngamide C, 8-epi-malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the marine cyanobacterium Lyngbya majuscula. Phytochemistry, 71(14-15), 1729-1735. PMCID: PMC2952490

Hall, J., Song, Y., Karplus, P. A., & Barbar, E. (2010). The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly. J Biol Chem, 285(29), 22566-22575. PMCID: PMC2903378

Jha, S. S., Danelishvili, L., Wagner, D., Maser, J., Li, Y. J., Moric, I., Vogt, S., Yamazaki, Y., Lai, B., & Bermudez, L. E. (2010). Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages. BMC Microbiol, 10, 100. PMCID: PMC2882924

Kesinger, N. G., Langsdorf, B. L., Yokochi, A. F., Miranda, C. L., & Stevens, J. F. (2010). Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal. Chem Res Toxicol, 23(4), 836-844. PMCID: PMC2858635

Kocisek, J., Papp, P., Mach, P., Vasil'ev, Y. V., Deinzer, M. L., & Matejcik, S. (2010). Resonance electron capture by serine. J Phys ChemA, 114(4), 1677-1683. PMID: 20043683

Kuiper, H. C., Langsdorf, B. L., Miranda, C. L., Joss, J., Jubert, C., Mata, J. E., & Stevens, J. F. (2010). Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study. Free Radic Biol Med, 48(1), 65-72. PMCID: PMC2818256

Maier, C. S., Chavez, J., Wang, J., & Wu, J. (2010). Protein adducts of aldehydic lipid peroxidation products identification and characterization of protein adducts using an aldehyde/keto-reactive probe in combination with mass spectrometry. Methods Enzymol, 473, 305-330. PMCID: PMC4191911

McPhail, K. L., Armstrong, D. J., Azevedo, M. D., Banowetz, G. M., & Mills, D. I. (2010). 4-Formylaminooxyvinylglycine, an herbicidal germination-arrest factor from Pseudomonas rhizosphere bacteria. J Nat Prod, 73(11), 1853-1857. PMCID: PMC3049220

Peluso, M. R., Miranda, C. L., Hobbs, D. J., Proteau, R. R., & Stevens, J. F. (2010). Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2). Planta Med, 76(14), 1536-1543. PMID: 20309792

Shchukin, P. V., Muftakhov, M. V., Morre, J., Deinzer, M. L., & Vasil'ev, Y. V. (2010). High resolution mass analysis of N- and C-terminal negative ions resulting from resonance electron capture by aliphatic amino acids. J Chem Phys, 132(23), 234306. PMID: 20572704

Stowell, C., Wang, L., Arbogast, B., Lan, J. Q., Cioffi, G. A., Burgoyne, C. F., & Zhou, A. (2010). Retinal proteomic changes under different ischemic conditions - implication of an epigenetic regulatory mechanism. Int J Physiol Pathophysiol Pharmacol, 2(2), 148-160. PMCID: PMC2926809

Takata, T., Smith, J. P., Arbogast, B., David, L. L., & Lampi, K. J. (2010). Solvent accessibility of betaB2-crystallin and local structural changes due to deamidation at the dimer interface. Exp Eye Res, 91(3), 336-346. PMCID: PMC2926248

Veluthoor, S., Li, S., Kelsey, R. G., Dolan, M. C., Panella, N. A., & Karchesy, J. (2010). Two new diterpene phenols from Calocedrus decurrans. Nat Prod Commun, 5(4), 519-522. PMID: 20433063

Zeng, X., Massey Simonich, S. L., Robrock, K. R., Korytar, P., Alvarez-Cohen, L., & Barofsky, D. F. (2010). Application of a congener-specific debromination model to study photodebromination, anaerobic microbial debromination, and FE0 reduction of polybrominated diphenyl ethers. Environ Toxicol Chem, 29(4), 770-778. PMCID: PMC3059408

Mass Spectrometry Center Publications_2009

Aminin, D. L., Koy, C., Dmitrenok, P. S., Muller-Hilke, B., Koczan, D., Arbogast, B., Silchenko, A. A., Kalinin, V. I., Avilov, S. A., Stonik, V. A., Collin, P. D., Thiesen, H. J., Deinzer, M. L., & Glocker, M. O. (2009). Immunomodulatory effects of holothurian triterpene glycosides on mammalian splenocytes determined by mass spectrometric proteome analysis. J Proteomics, 72(5), 886-906. PMID: 19410666

Chung, W. G., Miranda, C. L., Stevens, J. F., & Maier, C. S. (2009). Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive oxygen species. Food Chem Toxicol, 47(4), 827-836. PMCID: PMC2888903

Gomez, L. A., Monette, J. S., Chavez, J. D., Maier, C. S., & Hagen, T. M. (2009). Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart. Arch Biochem Biophys, 490(1), 30-35. PMCID: PMC2762268

Hall, A., Parsonage, D., Horita, D., Karplus, P. A., Poole, L. B., & Barbar, E. (2009). Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds. Biochemistry, 48(25), 5984-5993. PMCID: PMC2744581

Hall, J., Karplus, P. A., & Barbar, E. (2009). Multivalency in the assembly of intrinsically disordered Dynein intermediate chain. J Biol Chem, 284(48), 33115-33121. PMCID: PMC2785153

Harder, M. E., Malencik, D. A., Yan, X., Broderick, D., Leid, M., Anderson, S. R., Deinzer, M. L., & Schimerlik, M. I. (2009). Equilibrium unfolding of the retinoid X receptor ligand binding domain and characterization of an unfolding intermediate. Biophys Chem, 141(1), 1-10. PMCID: PMC2805030

Isaacson, C. W., Kleber, M., & Field, J. A. (2009). Quantitative analysis of fullerene nanomaterials in environmental systems: a critical review. Environ Sci Technol, 43(17), 6463-6474. PMCID: PMC2749266

Kesinger, N. G., & Stevens, J. F. (2009). Covalent interaction of ascorbic acid with natural products. Phytochemistry, 70(17-18), 1930-1939. PMCID: PMC278791

McClintock, S. P., Forster, N., Herges, R., & Haley, M. M. (2009). Synthesis of alpha-ketoester- and alpha-hydroxyester-substituted isoindazoles via the thermodynamic coarctate cyclization of ester-terminated azo-ene-yne systems. J Org Chem, 74(17), 6631-6636. PMCID: PMC4154358

Miranda, C. L., Reed, R. L., Kuiper, H. C., Alber, S., & Stevens, J. F. (2009). Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells. Chem Res Toxicol, 22(5), 863-874. PMCID: PMC2730585

Scheri, R. C., Lee, J., Barofsky, D. F., & Curtis, L. R. (2009). Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins. Toxicol Lett, 191(1), 20-25. PMCID: PMC4126231

Stevens, J. F., Reed, R. L., Alber, S., Pritchett, L., & Machado, S. (2009). Herbicidal activity of glucosinolate degradation products in fermented meadowfoam ( Limnanthes alba ) seed meal. J Agric Food Chem, 57(5), 1821-1826. PMCID: PMC2880616

Vasil'ev, Y. V., Figard, B. J., Morre, J., & Deinzer, M. L. (2009). Fragmentation of peptide negative molecular ions induced by resonance electron capture. J Chem Phys, 131(4), 044317. PMCID: PMC2730708

Voinov, V. G., Beckman, J. S., Deinzer, M. L., & Barofsky, D. F. (2009). Electron-capture dissociation (ECD), collision-induced dissociation (CID) and ECD/CID in a linear radio-frequency-free magnetic cell. Rapid Commun Mass Spectrom, 23(18), 3028-3030. PMCID: PMC3057201

Voinov, V. G., Deinzer, M. L., & Barofsky, D. F. (2009). Radio-frequency-free cell for electron capture dissociation in tandem mass spectrometry. Analytical Chemistry, 81(3), 1238-1243. PMCID: PMC3066179

Yan, X., & Maier, C. S. (2009). Hydrogen/deuterium exchange mass spectrometry. Methods Mol Biol, 492, 255-271.

Mass Spectrometry Center Publications_2008

Chung, W. G., & Maier, C. S. (2008). Identification and characterization of oxylipid-protein and peptide conjugates by mass spectrometry. Curr Protoc Toxicol, Chapter 17, Unit 17 19. PMID: 23045005

Chung, W. G., Miranda, C. L., & Maier, C. S. (2008). Detection of carbonyl-modified proteins in interfibrillar rat mitochondria using N'-aminooxymethylcarbonylhydrazino-D-biotin as an aldehyde/keto-reactive probe in combination with Western blot analysis and tandem mass spectrometry. Electrophoresis, 29(6), 1317-1324. PMID: 18348219

Henderson, M. C., Siddens, L. K., Morre, J. T., Krueger, S. K., & Williams, D. E. (2008). Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicol Appl Pharmacol, 233(3), 420-427. PMCID: PMC2626250

Huset, C. A., Chiaia, A. C., Barofsky, D. F., Jonkers, N., Kohler, H. P., Ort, C., Giger, D. W., & Field, J. A. (2008). Occurrence and mass flows of fluorochemicals in the Glatt Valley watershed, Switzerland. Environ Sci Technol, 42(17), 6369-6377. PMCID: PMC3056649

Kuiper, H. C., Miranda, C. L., Sowell, J. D., & Stevens, J. F. (2008a). Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress. J Biol Chem, 283(25), 17131-17138. PMCID: PMC2427341

Schilke, K. F., & Kelly, C. (2008). Activation of immobilized lipase in non-aqueous systems by hydrophobic poly-DL-tryptophan tethers. Biotechnol Bioeng, 101(1), 9-18. PMCID: PMC4124937

Stevens, J. F., & Maier, C. S. (2008). Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease. Mol Nutr Food Res, 52(1), 7-25. PMCID: PMC2423340

Stevens, J. F., Reed, R. L., & Morre, J. T. (2008). Characterization of phytoecdysteroid glycosides in Meadowfoam (Limnanthes alba) seed meal by positive and negative ion LC-MS/MS. J Agric Food Chem, 56(11), 3945-3952. PMCID: PMC2574805

Voinov, V. G., Deinzer, M. L., & Barofsky, D. F. (2008). Electron capture dissociation in a linear radiofrequency-free magnetic cell. Rapid Commun Mass Spectrom, 22(19), 3087-3088. PMCID: PMC3045275

Xu, H., Minagawa, K., Bai, L., Deng, Z., & Mahmud, T. (2008). Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A. J Nat Prod, 71(7), 1233-1236. PMCID: PMC2574543

Zeng, X., Massey Simonich, S. L., Robrock, K. R., Korytar, P., Alvarez-Cohen, L., & Barofsky, D. F. (2008). Development and validation of a congener-specific photodegradation model for polybrominated diphenyl ethers. Environ Toxicol Chem, 27(12), 2427-2435. PMCID: PMC3056650